摘要
目的探讨Survivin和PTEN蛋白在鼻咽癌（NPC）组织中的表达及其临床意义。方法应用免疫组织化学方法检测68例NPC和20例鼻咽黏膜慢性炎组织中Survivin和PTEN表达,并分析其与临床分期、病理组织类型和转移的关系。结果在NPC中,Survivin和PTEN阳性表达率分别为84.5%（49/68）和51.5%（35/68）。Survivin高表达和PTEN低表达与NPC的临床分期、组织学分型和颈部淋巴结转移相关（χ2=5.21～9.99,P〈0.05）。结论Survivin和PTEN表达与NPC的分化程度和转移相关,检测其表达可作为判断NPC预后的客观指标。
Objective To study the expression and its clinical significance of Survivin and PTEN protein in nasopharygeal carcinoma （NPC）. Methods Immunohistochemical method was used to determine the expression of Survivin and PTEN protein in 68 cases of NPC and 20 cases of chronic inflammation of nasopharyngeal mucosa. The relationship between the gene expression and clinicopathological features,metastasis was analyzed. Results The positive expression rate of Survivin and PTEN in NPC was 8,1.5 %（49 /68） and 51.5/ （35/68）,respectively. The high level expression of Survivin and the lowlevel expression of PTEN were positively correlated with the clinicopathological features,tissue types and neck lymph node metastasis in NPC （x^2=6.21- 9.99,P〈0.05）. Conclusion These data show a correlation between the Survivin and PTEN expression and the differentiation and metastasis in NPC. The detection of the expression may be used as an objective index to judge the prognosis of NPC.
出处
《青岛大学医学院学报》
CAS
2008年第4期331-332,334,共3页
Acta Academiae Medicinae Qingdao Universitatis
