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消化性溃疡患者血清c反应蛋白和肿瘤坏死因子α水平测定的临床意义 被引量:10

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摘要 目的研究血清炎症因子C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)在消化性溃疡(PU)活动(A)期与瘢痕(S)期的变化。方法PU123例,其中幽门螺杆菌(Hp)阳性(+)A期53例和S期12例;Hp阴性(-)A期20例和S期38例;健康对照组30例。全部参试者均测定血清CRP、TNF-α和电子胃镜检查。结果PU无论是Hp(+)和Hp(-)的A期与S期,CRP、TNF-α值均高于对照组,且除Hp(-)S期与对照组比较无统计学意义(P>0.05)外,其它各组与之比较P均<0.05;组间比较除Hp(+)S期与Hp(+)A期比较,Hp(+)S期与Hp(-)A期比较无统计学意义外(P>0.05),其它组间比较都有统计学意义(P<0.05)。结论消化性溃疡患者血清CRP、TNF-α水平升高,可反映疾病处于炎症活动期;CRP与TNF-α的测定可作为判断消化性溃疡病变程度及疗效的参考指标。
作者 姚莉亚 徐立
出处 《现代消化及介入诊疗》 2008年第3期214-216,共3页 Modern Interventional Diagnosis and Treatment in Gastroenterology
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