摘要
目的:观察氯吡格雷对动脉粥样硬化(AS)家兔血清高敏C-反应蛋白(hs-CRP)和血管壁核因子-κB(NF-κB)水平的影响。方法:27只新西兰雄性白兔随机分为正常对照组(NC)、高胆固醇组(HC)和高胆固醇加氯吡格雷组(HC+C)。采用固相酶联免疫吸附试验(ELISA)定量测定血清hs-CRP及主动脉弓血管壁NF-κB含量;组织形态学分析AS斑块/内膜面积比值及斑块最厚处内/中膜厚度比值。结果:HC+C组与HC组相比,斑块/内膜的面积比下降39.59%,内膜/中膜厚度比下降41.57%(P<0.01);血管壁NF-κB及血清hs-CRP含量亦明显降低(P<0.05)。结论:氯吡格雷具有抗AS作用和抗炎作用。
OBJECTIVE To observe the effects of ADP receptor blocker clopidogrel on the levels of serum （hs CRP） and nuclear factor-kappa B（NF-κB） in atherosclerotic plaque in rabbit models. METHODS Twenty-seven New Zealand male rabbits were randomly divided into normal control group（NC group, n = 9）, high-cholesterol group（ HC group, n = 9） and high-cholesterol plus clopidogrel group（HC ＋ C group, n = 9） and then were fed for 12 weeks, enzyme-linked immunosorbent assay （ELISA） was employed to monitor the levels of serum hs-CRP and plaque tissue NF-κB in vascular wall, the plaque area of aor ta and the neointima thickness were performed with histomorphometry analysis. RESULTS The levels of serum hs-CRP and vascular wall NF-κB p65 subunit, the neointima thickness and plaque area of aorta in the HC group and HC＋ C group were sig nificantly increased compared with the NC group（P〈0. 05）. There was no significantly difference in the serum lipids between the HC group and HC ＋ C group（P〉0. 05）, the levels of serum hs-CRP and vascular wall NF-κB p65, the neointima thickness and plaque area of aorta in the HC＋ C group were significantly decreased compared with the NC group（P〈0. 05）. CONCLUSION The study suggested that clopidogel could decrease atherosclerosis and inflammation.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第13期1074-1077,共4页
Chinese Journal of Hospital Pharmacy
