摘要
酰基辅酶Ａ：胆固醇酰基转移酶（ＡＣＡＴ）可将体内胆固醇转化为胆固醇酯，并参与多种生理功能。病理条件下ＡＣＡＴ能诱发并加重动脉粥样硬化，其抑制剂则有降血脂、抗动脉粥样硬化的功效。本文介绍ＡＣＡＴ抑制剂的发展概况、分类和药理作用。
Acyl-coenzyme A:cholesterol acyltransferase(ACAT) catalyzes the intracelluar esterification of cholesterol and plays an important part in the maintenance of cholesterol homeostasis.In pathological conditions,it is believed to be responsible for the development of the atherosclerotic lessions.Therefore,ACAT inhibitors should be used clinically in preventing both hypercholesterolemia and atherosclerosis by blocking cholesterol esterification.In this article,we present the profile of the types,the pharmacological effects and the development of ACATinhibitors .
出处
《药学进展》
CAS
1997年第4期193-199,共7页
Progress in Pharmaceutical Sciences
关键词
抑制剂
脂蛋白
动脉粥样硬化
酰基辅酶A
ACATInhibitors Lipoprotein Atherosclerosis Cholesterol Cholesterolester
