摘要
目的用6分钟步行试验（6MWT）和多普勒超声心动图，评价曲美他嗪辅助治疗缺血性心肌病心力衰竭的疗效。方法采用随机、单盲及组间对照，共选取96例因缺血性心肌病而导致慢性心力衰竭者（NYHAⅡ～Ⅳ级）。将患者分为两组，曲美他嗪组（50例，常规治疗＋曲美他嗪20mg／次，3次／天）和对照组（46例，常规治疗），疗程为3个月，观察两组治疗前后左室收缩末期内径（ESD）、左室舒张末期内径（EDD）、左室收缩末期容积（ESV）、左室舒张末期容积（EDV）、短轴缩短分数（FS）、心搏量（SV）、左室射血分数（EF）、6分钟步行距离。结果用药3个月后，组间比较显示曲美他嗪组的ESD、ESV、FS、SV、EF及6分钟步行距离比对照组有进一步的改善。结论常规治疗缺血性心肌病心力衰竭的基础上加用曲美他嗪可以进一步改善患者的心脏收缩功能，提高患者的运动耐量。耐受性良好。
Objective Trimetazidine was evaluated as an auxiliary agent for ischemia cardiomyopathy complicated with heart failure by 6 minutes walk test and Doppler echocardiography. Methods A random, single blinded, between-group contrastive study was carried out in 96 cases of ischemia cardiomyopathy complicated with heart failure （ NYHA Ⅱ - Ⅳ grade） . All patients were classified into two groups, Trimetazidine group （50 cases, routine therapy plus trimetazidine 20 mg once, three times on day, and control group （46 cases, routine therapy） . The course of treatment for 3 months observed the left ventricular end diastolic diameter （EDD）, left ventricular end systolic diameter （ESD）, left ventricular end-diastolic volume （EDV）, left ventricular end-systolic volume （ESV）, fractional shortening （FS）, systolic volume （SV）, left ventricular eject fraction （ LVEF）, and 6 minutes walk before and after treatment. Results After treatment 3 months long, comparison between groups showed trimetazidine group gained better effect than control group in ESD, ESV, FS, SV, EF and 6 min walk. Conclusion Routine treatment added with trimetazidine for ischemia cardiomyopathy complicated with heart failure can further improve the systolic function of heart and increase the exercise tolerance, besides, drug tolerability is satisfactory.
出处
《广州医药》
2008年第5期22-23,共2页
Guangzhou Medical Journal
关键词
曲美他嗪
缺血性心肌病
心力衰竭
Trimetazidine
Ischemia cardiomyopathy
Heart failure
