摘要
报道从Ｄ－甘露醇出发合成手性双膦（２Ｓ，５Ｓ）－３，６－双（二苯膦）－１，４∶３，６－双脱水－２，５－双去氧－Ｌ－艾杜醇（ＢＤＰＩ，Ⅲ）．原位下ＢＤＰＩ与３种铑配合物作用生成手性非螯合型双膦铑催化剂，常压下对４种脱氢苯丙氨酸衍生物进行不对称催化氢化反应．对反应结果及ｅ．ｅ．值进行了讨论．
Rhodium complexes of NBD (Norbornadiene), COD(1,5 cyclooctadiene) and acac (acetyacetonyl) coordinated with chiral diphosphine(2 S ,5 S ) 3,6 bis(diphenylphosphino) 1,4∶3,6 dianhydro 2,5 dideoxy L iditol was synthesized in situ and used as catalyst for asymmetric hydrogenation of dehydrophenylalanine derivatives. In all cases ( R ) enantiomers were formed in excess. The results were discussed in detail.
出处
《分子催化》
EI
CAS
CSCD
北大核心
1997年第6期421-426,共6页
Journal of Molecular Catalysis(China)
关键词
不对称氢化
手性双膦
苯丙氨酸衍生物
铑配合物
Asymmetric hydrogenation, Chiral diphosphine, Rh phosphine complexes, Phenylalanine derivatives
