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DABO类非核苷类逆转录酶抑制剂分子设计及合成 被引量：1

Molecule design and synthesis of novel DABO derivatives as NNRTIs
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摘要 基于非核苷类逆转录酶抑制剂DABO类似物的构效关系,设计了4个新的DABO类化合物,并采用微波催化的方法进行了合成,最后通过1H NMR,13C NMR及IR对目标分子进行了结构表征. Based on the structure and activity relationship （ SAR ） of dihydroalky-loxybenzyloxopyrimidines （DABOs） as non- nucleoside reverse transcriptase inhibitors（NNRTIs）, four novel.DABO derivatives were designed and synthesied by microwave irradiation. The structure of the products were further conformed by ^1 HNMR,^13CNMR and IR.
作者 张虽栓 辛七四 何严萍 李聪 何嵋
机构地区 云南大学化学科学与工程学院教育部自然资源药物化学重点实验室
出处 《云南大学学报（自然科学版）》 CAS CSCD 北大核心 2008年第5期514-518,共5页 Journal of Yunnan University(Natural Sciences Edition)
基金 国家自然科学基金资助项目(30560179)
关键词 非核苷类逆转录酶抑制剂 DABO类似物 微波催化合成 NNRTIs DABO derivatives microwave mediated synthesis
分类号 R978.7 [医药卫生—药品]
  • 相关文献

参考文献21

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共引文献44

同被引文献15

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二级引证文献1

云南大学学报（自然科学版）
2008年 第5期

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