摘要
目的:研究大肠癌中MMP-2、MMP-9与IV型胶原的表达及其相关性。方法:对30例Dukes'B、C期大肠癌患者的癌组织和正常组织进行IV型胶原、MMP-2、MMP-9的免疫组织化学检测,并进行相关性分析。结果:IV型胶原在大肠癌组织中的表达明显降低;MMP-2、MMP-9在大部分正常大肠组织中均未见表达,仅少数见到有阳性表达,而在癌组织中表达明显增强。IV型胶原评分与MMP-9表达之间呈负相关。结论:大肠癌组织中IV型胶原的表达明显降低,MMP-9对大肠癌中IV型胶原的降解起着重要作用。
AIM： To investigate the expression of MMP- 2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas. METHODS： The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes＇B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed. RESULTS： The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9. CONCLUSION： The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2008年第9期908-909,912,共3页
Chinese Journal of Cellular and Molecular Immunology
基金
国家高技术研究发展计划(863)资助项目(2006AA02Z437)
关键词
大肠肿瘤
IV型胶原
基质金属蛋白酶
免疫组化
colorectal cancer
collagen type IV
matrix metalloproteinase
immunohistochemistry
