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生物医用功能材料前驱体壳寡糖接枝聚己内酯的制备与表征 被引量:4

Preparation and characterization of biomedical functional material precursor chitosan oligosaccharide-g-polycaprolactone
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摘要 采用邻苯二甲酸酐保护壳寡糖的氨基制备了N-邻苯二甲酰化壳寡糖中间体,又通过引发剂辛酸亚锡引发ε-己内酯开环接枝聚合和脱去保护基的方法制备了新型生物医用功能材料前驱体壳寡糖接枝聚己内酯共聚物,该前驱体可进一步进行活性氨基的化学修饰。采用傅立叶红外光谱(FT-IR)、X射线衍射(XRD)、示差扫描量热仪(DSC)对N-邻苯二甲酰化壳寡糖接枝聚己内酯共聚物的化学结构、结晶性和热性能进行了表征。结果表明随着ε-己内酯与N-邻苯二甲酰化壳寡糖的摩尔比增加,接枝共聚物的DSC曲线出现了聚己内酯侧链的熔融峰,XRD也表明,壳寡糖分子不完善的结晶区被破坏,并在此基础上形成了新的均聚物聚己内酯(PCL)侧链的结晶区。 A novel biomedical functional material precursor, chitosan oligosaccharide-g-polycaprolactone, was synthesized via the amino groups protection procedure with phthalic anhydride to prepare phthaloyl chitosan oli- gosaccharide precursor. The graft polymerization was carried out by coupling the hydroxyl group via the ring-o- pening graft copolymerization of ε- caprolactone in the presence of tin( Ⅱ ) 2-ethylhexanoate ( stannous octoate) catalyst and removing the protective N- phthaloyl group. The prepared copolymers precursor can be used to further undergo chemoselective modification reactions through the active amino groups. The chemical structure , crystallinity and thermol propertity of the obtained N-phthaloyl chitosan oligosaccharide-g-polycaprolactone were characterized by Fourier transform infrared (FTIR) spectra, X-ray diffraction (XRD)and DSC. It was found that the copolymer could form melting endothermol peak of polycaprolactone side chains in DSC curve with the increasing of the mole ratio of ε- caprolactone to phthaloyl chitosan oligosaccharide. X-ray diffraction also showed that a new crystal domain of polycaprolactone occurred in the N-phthaloyl-chitosan oligosaccharide- g-polycaprolactone copolymer while the crystal structure of chitosan oligosaccharide was damaged.
出处 《功能材料》 EI CAS CSCD 北大核心 2008年第9期1511-1514,共4页 Journal of Functional Materials
基金 国家自然科学基金资助项目(50673015) 国家高技术研究发展计划(863计划)资助项目(2006AA02Z291)
关键词 壳寡糖 己内酯 功能材料前驱体 制备 表征 chitosan oligosaccharide ε-caprolactone functional material precursor preparation characterizations
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参考文献24

  • 1蒋挺大.甲壳素[M].北京;化学工业出版社,2002.22.
  • 2Eastmond G C. [J]. Adv Polym Sei, 2000, 149: 59-233.
  • 3Albertsson A C, Varma I K. [J]. Biomacromolecules, 2003, 4:1466-1486.
  • 4Tuzlakoglu K, Alves C M, Mano J F, et al. [J]. Macromol Biosei, 2004, 4:811-819.
  • 5Jeon Y J, Park P J, Kim S K. [J]. Carbohyd Polym, 2001, 44: 71-76.
  • 6Tokoro A, Tatewaki N, Suzuki K , et al. [J]. Chem Pharm B, 1988, 36:784-790.
  • 7Hirano S, Iwata M, Yamanaka K, et al. [J]. Agr Biol Chem, 1991, 55: 2623-2625.
  • 8Prashanth K V H, Tharanathan R N. [J]. Biochimica et Biophysica Acta, 2005,1722 : 22-29.
  • 9Griffith L G. [J]. Aeta Mater, 2000,48: 263-277.
  • 10Hutmacher D W.[J]. Biomaterials, 2000, 21: 2529-2534.

二级参考文献8

  • 1孟宪举,张策,詹梅晶,师忠秀.含间隙连杆机构精度概率分析模型[J].机械设计,2004,21(9):35-37. 被引量:20
  • 2杨玉虎,洪振宇,张策.机构位置误差分析的传递矩阵法[J].机械工程学报,2005,41(2):20-23. 被引量:33
  • 3黄家贤.机构精度通用新算法的推导及应用举例[J].机器人,1995,17(6):337-342. 被引量:4
  • 4Innocenti C. A static-based method to evaluate the effect of joint clearance on the positioning errors of planar mechanisms [C]//Proceedings of the 10th World Congress on the Theory of Machines and Mechanism. Oulu, Finland: IFTOMM, 1999:650 - 665.
  • 5Earles S W E, Senevirame L D. Some kinematic effects of clearances in revolute joints of linkage mechanisms [ C ] // Proceedings of the 7th World Congress on the Theory of Machines and Mechanism. Sevilla: IFTOMM, 1987:523 - 528.
  • 6Parenti-Castelli V, Venanzi S. A new technique for clearance influence analysis in planar mechanisms [ C ]//ASME 2002 Design Engineering Technical Conferences and Computer and Information in Engineering Conference. Montreal: ASME, 2002:1003- 1009.
  • 7Ting K L, Zhu J M, Watkins D. The effects of joint clearance on position and orientation deviation of linkages and manipulators[J]. Mechanism and Machine Theory, 2000,35 (3) :391-401.
  • 8Tsai M J, Lai T H. Accuracy analysis of multi-loop linkage with joint clearances [J ]. Mechanism and Machine Theory, 2008,43(9):1141 -1157.

共引文献13

同被引文献66

  • 1艾合麦提.玉素甫,陈统一,陈中伟,刘大鹏,王振斌.可降解聚己内酯修复骨缺损的实验研究[J].中国修复重建外科杂志,2005,19(6):439-442. 被引量:12
  • 2Lu J X, Prudhommeaux F, Meunier A. [J]. Biomaterials, 1999,20(20) : 1937-1944.
  • 3Lahiji A, Sohzabi A, Hungerford D S. [J]. J Biomed Mater Res,2000,51(4) :586-595.
  • 4Chupa J M, Foster A M, Sumner S R. [J]. Biomaterials, 2000,21(22):2315-2322.
  • 5Liu L,Li Y,Liu H,et al. [J]. European Polymer Journal, 2004,40(12) :2739-2744.
  • 6Liu L,Wang Y S,Shen X F,et al. [J]. Biopolymers,2005, 78(4): 163-170.
  • 7Detchprohm S, Aoi K, Okada M. [J]. Macromol Chem Phys, 2001,202 (18) : 3560-3570.
  • 8Yu H J,Wang W S, Chen X S,et al. [J]. Biopolymers, 2006,83 (3) : 233-242.
  • 9Liu L, Li Y P, Li Y, et al. [J]. Carbohydrate Polymers, 2004,57(1) :97-100.
  • 10Lu Y Y,Liu L,Guo S R. [J], Biopolymers,2007,86(5-6) : 403-408.

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