摘要
目的确定o/w型依托泊苷微乳处方。方法选用油酸、十四酸异丙酯和十六酸异丙酯作为油相,Tween80、Cremophor EL和Cremophor RH40作为表面活性剂,乙醇、1,2-丙二醇、异丙醇、甘油和PEG 400为助表面活性剂,通过滴定法绘制伪三元相图,以o/w型微乳区大小为指标筛选处方。结果确定了最终空白微乳处方为Cremophor RH40∶乙醇∶PEG 400∶水∶十四酸异丙酯=19.0∶19.0∶19.0∶38.2∶4.8(w/w)。结论所选择的微乳处方可以满足依托泊苷载药量的要求。
Objective To develop the o/w etoposide microemulsion formulation. Methods Oleic acid, isopropyl myristate and isopropyl palmitate were chosen for oils. Tween 80 , Cremophor EL and Cremophor RH40 were selected as surfactants. Ethanol, isopropyl alcohol, 1, 2-propylene glycol, glycerin and PEG 400 were used as cosurfactants. The pseudotertiary phase diagrams were obtained by titration. The formulation was screened by the o/w microemulsion area. Results The final blank microemulsion formulation was： cremophor RH40 ： ethanol ： PEG 400 ： isopropyl miristate ： water=19.0 ： 19.0 ： 19.0 ： 38.2 ： 4.8. Conclusion The defined microemulsion formulation can be used to carry etoposide.
出处
《中南药学》
CAS
2008年第5期516-519,共4页
Central South Pharmacy
基金
"国家科技支撑计划"子课题
新型载体给药系统及其成药性综合评价关键技术与应用研究(项目编号:2007BAI41B05)
关键词
微乳
依托泊苷
伪三元相图
microemulsion
etoposide
pseudoternary phase diagram
