摘要
目的观察复方蜂胶口服液抗胃溃疡的药效,以及对胃液分泌的影响。方法利用利血平、乙酸烧灼、幽门结扎3种溃疡模型,以及胃液分泌及成分分析实验,与西咪替丁、纯化水对照,观察实验动物的溃疡情况。结果复方蜂胶口服液可显著抑制利血平溃疡的形成,对乙酸烧灼型溃疡的愈合有明显的促进作用,可显著抑制幽门结扎溃疡的形成,并显著减少溃疡面积,其作用与阳性对照药西咪替丁相当。复方蜂胶口服液能显著降低胃液量、胃液总酸度、1 h总酸排出量,显著抑制胃蛋白酶的活性。结论复方蜂胶口服有明显的的抗溃疡作用。
Objective To evaluate the efficacy of complex fengjiao oral solution on stomach ulcer and its influence on gastric juice secretion. Methods Ulcerating rates and their severities were measured after the purified water or cimetidine or underestimated oral solution was administrated to the ulcer models, which was pretreated with reserpine or acetate acid or by pyloric ligation respectively. Gastric juice secretion and pepsin activities were analyzed. Results Ulcer rates and ulcer numbers induced by reserpine were inhibited significantly. The ulcer acreages were reduced in the acetate acid treatment group, the ulcer numbers and areas were decreased in the pyloric ligation group after being treated with complex fengjiao oral solution. No statistical difference was found when compared with those of the cemitidine treatment group. Volume of gastric juice, total acidity and total acid secreted in 1 h were decreased obviously, and the bio-activity of pepsin was inhibited as well. Conclusion The anti-ulcer efficacy of complex fengjiao oral solution on stomach ulcer was significant.
出处
《中南药学》
CAS
2008年第5期539-541,共3页
Central South Pharmacy
关键词
复方蜂胶口服液
胃溃疡
胃酸
胃蛋白酶
complex fengjiao oral solution
stomach ulcer
gastric acid
pepsin
