摘要
目的:探讨脑梗死患者血清超敏C-反应蛋白(hs-CRP)水平的变化及神经功能缺损的关系,进而了解他汀类药物对脑梗死患者血清hs-CRP水平及预后的影响。方法:采用随机、双盲、安慰剂对照的方法进行研究,将40例脑梗死患者分为对照组和他汀组(辛伐他汀40mg/d,连续2周),治疗前后检测血清hs-CRP水平,并进行神经功能缺损评分比较。结果:他汀组血清hs-CRP水平降低明显,与对照组比较有显著性差异(P<0.05),神经功能缺损程度评分比较他汀组下降较明显,与对照组比较有显著性差异(P<0.05)。结论:脑梗死患者血清hs-CRP与预后相关,应用他汀类药物可以降低脑梗死患者血清CRP水平,能在一定程度上改善预后。
Objective To study the relationship between serum high sensitivity C- reactive protein （ hs - CRP） and neurological functional deficit scales after cerebal infarction so as to evaluate effect of statins on hs- CRP levels and prognosis . Methods Forty cerebral infarction patients were divided by random , doubl - blind and placebo contrasstive methods into the control group and statins group （40 mg/d of simvastatin for 2 weeks ） . The serum levels of hs - CRP were detected before and after treatment. The neurological functional deficit scales of all patients were examined. Results The tevds of serum hs - CRP and the neurological functional deficit scales in statins group decreased significantly compared with control group （ P 〈0.05） . Conclusions The levels of serum hs- CRP are associated with prognosis of cerebral infarction, statins can reduce levels of serum hs - CRP so as to improve prognosis.
关键词
脑梗死
他汀类药物
C-反应蛋白
预后
Cerebral infarction
Statins
High Sensitivity C- reactive protein
Prognosis
