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培美曲塞抑制肺腺癌细胞侵袭能力的研究 被引量：1

Inhibition of Premetrexed on Invasion of Lung Adenocarcinoma Cell
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摘要 [目的]探讨纤连蛋白(FN)对非小细胞肺癌的黏附和迁移能力的影响及培美曲塞的干预作用。[方法]以肺腺癌细胞系A549为研究对象,观察FN对癌细胞增殖活性的影响及不同浓度培美曲塞的抑制作用。在FN包被的培养板和FN滤膜的Boyden浸润小室等体外侵袭模型中,观察培美曲塞预处理后细胞与FN黏附及迁移能力的变化。设立牛血清白蛋白作为FN的对照组。[结果]FN能明显提高A549细胞的增殖活性,培美曲塞40nmol/L和80nmol/L能有效抑制这种增殖活性的升高,但低浓度20nmol/L培美曲塞的抑制作用却不显著。A549细胞在FN培养板的黏附数量及在小室中的穿膜数量远高于对照组,而各浓度培美曲塞预处理细胞的黏附及迁移能力明显降低。[结论]FN能促进肺腺癌细胞的增殖活性、黏附和迁移能力,培美曲塞能在一定程度上阻断这种效应。
作者 李文 宋立强 刘吉福
机构地区 中国人民解放军北京军区总医院 第四军医大学西京医院
出处 《肿瘤学杂志》 CAS 2008年第9期732-734,共3页 Journal of Chinese Oncology
关键词 癌 非小细胞肺 纤连蛋白类 培美曲塞 肿瘤侵润
分类号 R734.2 [医药卫生—肿瘤]
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参考文献10

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二级参考文献19

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肿瘤学杂志
2008年 第9期

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