摘要
目的检测缺氧缺血性脑病（HIE）新生儿血清IgG、IgA、IgM及C3、C4的变化，了解HIE对免疫功能的影响。方法HIE患儿172例，根据年龄、病情轻重分为1～3天组84例，其中轻度HIE36例，中重度HIE48例；4～7天组88例，其中轻度HIE41例，中重度HIE47例。对照组86例为同期住院非HIE足月新生儿。检测血清IgG、IgA、IgM及C3、C4，相关结果进行统计学分析。结果1—3天组和4—7天组轻度HIE及中重度HIE患儿血清IgM、C3、C4均低于对照组（P〈0．05），轻度HIE及中重度HIE患儿血清IgG、IgA与对照组差异均无统计学意义（P〉0．05）；1～3天组和4～7天组轻度HIE及中重度HIE患儿间血清IgG、IgA、IgM、C3、C4差异均无统计学意义（P〉0．05）。结论HIE可使患儿IgM及补体水平降低，但与HIE的程度无关。
Objective To investigate tbe changes of serum IgG, IgA, IgM, C3 and C4 in neonates with hypoxic - ischemic encephalopathy （HIE）. Methods 172 neonates with HIE and 86 non - HIE normal full - term infants were recruited in the study. The HIE neonates were divided into a 1 - 3 day group （ n = 84） and a 4 - 6 day group （ n = 88）, which were further divided into mild and moderate - severe subgroups. The Igs and complements in serum were determined by radial immunodiffusion assay. Results The levels of IgM, C3 and Ca were lower in both 1 - 3 day and 4 - 6 day groups than in the control （P 〈 0.05 ）. But the levels of IgG and IgA did not show such differences significantly （P 〉 0.05 ）. No significant differences in the results were found between the two age groups of the babies, or the varied severities of HIE, in the varied Igs and complements （ P 〉 0. 05）. Conclusion The levels of IgM, C3 and C4 are lowered in HIE neonstes, but the severity of HIE does not contribute to these changes.
出处
《徐州医学院学报》
CAS
2008年第9期614-616,共3页
Acta Academiae Medicinae Xuzhou
关键词
缺氧缺血性脑病
新生儿
免疫功能
hypoxic - ischemic encephalopathy
neonates
immune function
