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肝癌患者血浆apoM水平与其他脂类的相关性研究 被引量:1

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摘要 目的分析肝癌患者血浆中载脂蛋白M(apoM)的水平,阐明apoM与其他脂蛋白或载脂蛋白的关系。方法应用dot-blotting技术检测36例肝癌患者及64名健康人血浆中apoM的水平,酶法及比浊法检测肝癌患者血浆中TG、TC、apoAI、apoB、Lp(a)、HDL-C、LDL-C;比较原发性肝细胞癌患者和健康人血浆中apoM的水平,并对apoM与其他脂蛋白的关系进行相关性分析。结果血浆apoM水平肝癌组(712.87±345.98)INT/mm2明显高于健康人组(433.70±79.53)INT/mm2(t=3.399,P<0.05),差异具有统计学意义。肝癌患者血浆中的TG、HDL-C、apoAⅠ和Lp(a)水平明显低于健康人,而TC、apoB和LDL-C水平与健康人差异无统计学意义(P>0.05)。以Pearson相关分析法检测健康人组血浆apoM与Lp(a)呈正相关(r=0.6275,P=0.0005),与HDL-C呈负相关(r=-0.4587,P=0.0161),与其他血脂成分无明显的相关性。肝癌患者血浆apoM与血脂参数无相关性。结论肝癌患者血浆apoM水平明显高于健康人,apoM分析有可能作为判断肝癌受损程度的一种辅助指标。
出处 《临床检验杂志》 CAS CSCD 北大核心 2008年第5期371-372,共2页 Chinese Journal of Clinical Laboratory Science
基金 国家自然科学基金资助项目(30570752)
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