摘要
为探讨根尖周病发病机理中细胞粘附分子的作用,本研究采用逆转录——多聚酶链反应方法,对22例根尖肉芽肿病灶进行研究。结果显示:细胞间粘附分子(ICAM—1)和血管细胞粘附分子(VCAM—1)在所有病例都可出现阳性表达结果,细胞粘附分子的活性增强,而未见内皮细胞白细胞粘附分子(ELAM—1)阳性表达,提示细胞粘附分子与根尖周病有着密切关系。由于细胞粘附分子表达的差异,使不同类型的炎症具有不同类型的炎性细胞浸润。
The purpose of this study was to discuss the role of cell adhesion molecules in the pathogenesis of periapical lesions. Human perioapical lesion tissue from 22 patients were tested by reverse transcriptase - polymerase chain reaction (RT - PCR). The results were as follows: RT-PCR analysis of the clinical samples revealed VCAM -1 and I CAM - 1 expressed in all cases, and the activily of cell adhesion molecules enhanced, but the expression of ELAM - 1 was not observed. These findings indicated that cell adhesion molecules may be closely associated with periapical lesions. The fact that inflammations have the infiltration of various inflammatory cells may be the result of the different expressions of cell adhension molecules.
出处
《口腔医学纵横》
CSCD
1997年第3期144-147,共4页
Journal of Comprehensive Stomatology
关键词
细胞粘附分子
根尖肉芽肿
多聚酶链反应
RT-PCR
cell adhesion molecules
periapical lesions-, reverse transcriptase-polymerase chain reaction
