摘要
最近诸多研究已经报道了骨髓干细胞在正常肝脏及一些肝脏病理条件下能够分化为有功能的肝细胞和胆管细胞且可修复受损肝脏.本综述就当前骨髓源性肝脏干细胞研究水平进行回顾,涵盖了最新的知识和已发表的文献,包括:来自动物模型的证据、可能的机制和条件,未来临床应用细胞移植治疗肝病的方式等.
Recently, many studies reported that bone marrow stem cells （BMSCs） had the ability to differentiate into hepatocytes and cholangiocytes in normal livers or in some pathologic environments and to generate functional hepatocytes to restore the injured livers by cell transplantation. This review is designed as a state-of-the-art survey taking into account current knowledge and published work, including the evidence from animal models, the possible mechanisms and conditions, future application modalities for the clinical use of cellular-derived therapeutics for patients with liver diseases.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第25期2859-2866,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30070235
No.30470508
湖南省自然科学基金资助项目
No.06JJ20081
湖南省中医药管理局科研基金资助项目
No.202064
No.204057
湖南省科技厅科研基金资助项目
No.04-SK-306-2
长沙市科技计划项目资助项目
No.K071532-11~~
关键词
肝脏疾病
骨髓细胞
移植
Liver disease
Bone marrow cells
Transplantation
