摘要
目的:观察羟考酮控释片(奥施康定)在中重度癌痛门诊患者个体化治疗中的疗效及安全性。方法:应用羟考酮控释片治疗76例中重度癌痛门诊患者,对其治疗剂量、患者的疼痛缓解情况、生活质量以及不良反应进行观察和评估。结果:76例中重度癌痛门诊患者使用羟考酮控释片的最小剂量为10mg/12h,最大剂量80mg/12h;平均滴定达总有效时间为3.2d(1～11d),疼痛强度评分(NRS)治疗前为6.87±1.25,治疗1周后为2.74±2.30,2周后为2.55±1.21;治疗1周后总有效率为84.2%,2周后为89.5%,治疗前后疼痛强度变化有统计学意义(P<0.01)。治疗前生活质量评分为(49±15)分,治疗2周后为(63±16)分(P<0.05)。用药期间,49例(64.5%)患者曾发生至少一种不良反应,最常见的不良反应依次为便秘44例(57.9%)、嗜睡28例(36.8%)、头晕19例(25.0%)、恶心呕吐17例(22.4%),无1例出现不能耐受的不良反应。结论:羟考酮控释片治疗中重度癌痛门诊患者疗效好,安全性高,给药方便,是治疗中重度癌痛门诊患者的首选药之一。
Objective：To investigate the efficacy and safety of individualizational controlled-release oxycodone （CR oxycodohe） in the treatment of outpatients with moderate-to-severe cancer pain, as well as quality of life（QOL）. Methods：Seventy-six outpatients with moderate-to-severe cancer pain were treated with oral CR oxycodone. Dose of the treatment, remission rate of pain, QOL, and adverse effects of outpatients were observed and evaluated. Results：CR oxycodone was administered at an initial dose of 10 mg every 12 b and titrated upwards according to the maximal dose of 80 mg every 12 h. The mean length of titration time was 3. 2 days（range 1-11 days）. The pain intensity measured by numerial rating scale （NRS） was 6. 87 ±1.25 before the treatment, 2.74 ± 2.30 after 1 week of the treatment, 2. 55 ± 1.21 after 2 weeks. Remission rate of pain was 84. 2% in 1 week after the treatment, 89. 5% in 2 week. The differences of remission rate pain before and after the treatment was significant（P 〈0.01 ）. Compared with pre-treatment （49 ± 15 ） , the scores of QOL in 2 weeks after the treatment （73 ± 16 ） was significantly improved in outpatients （P 〈 0. 05 ）. Ouring CR oxycodone treatment, 49 （64. 5% ） reported for one adverse effect at least, including constipation 44 （57. 9% ）, sleepy 28 （ 36. 8% ）, dizzyl 9 （ 25.0% ）, and nauseatingl 7 （ 22.4% ）. Conclusion ： CR oxycodone is efficient and convenient for outpatients with moderate-to-severe cancer pain. It has less adverse reaction, and further warrant to using.
出处
《临床肿瘤学杂志》
CAS
2008年第9期836-838,共3页
Chinese Clinical Oncology
关键词
羟考酮控释片
门诊患者
癌痛
生活质量
Controlled-release oxycodone
Outpatients
Cancer pain
Quality of life
