期刊文献+

通过药物相关基因检测完善药品不良反应监测体系 被引量:3

下载PDF
导出
摘要 药物在人体内代谢的过程中涉及到许多酶、转运蛋白和受体等,它们与药品不良反应有很大关系。由于个体存在基因差异,使得药物最终药效会有很大差别。对已知不良反应的分析若加以先进科技手段的应用,对药物相关基因进行检测,就能够更准确更有效地分析不良反应,以期达到能够最大程度地预防不良反应的发生。
出处 《医药导报》 CAS 2008年第10期1276-1277,共2页 Herald of Medicine
  • 相关文献

参考文献8

二级参考文献94

  • 1王军升,许振华,周宏灏.细胞色素P4503A4与药物氧化代谢[J].中国临床药理学杂志,1996,12(4):231-235. 被引量:13
  • 2Anderson JL,Carlquist JF,Home BD,et al. Cardiovascular pharmacogenomics:current status,future prospects[J]. J Cardiovasc Pharmacol Ther,2003,(1):1.
  • 3Evans WE,Relling MV. Pharmacogenomics:translating functional genomics into rational therapeutics[J]. Science,1999,86(5439) :87.
  • 4Eiselt R,Domanski TL,Zibat A,et al. Identification and functional characterization of eight CYP3A4 protein variants [J]. Pharmacogenetic,2001,1(5):47.
  • 5Sata F,Sapone A,Elizondo G,et al. CYP3A4 allelic variants with amino acid substitutions in axons 7 and 12:0 evidence for an allelic variant with altered catalytic activity[J]. Clin Pharmacol Ther ,000,67(1):8.
  • 6Felix CA,Walker AH,Lange BJ,et al. Association of CYP3A4 genotype with treatment related leukemia [J]. Proc Natl Acad Sci USA,1998,5:3176.
  • 7Harinder SM,Karen LG. Atorvastatin an updated review of its pharmacological properties and use in dyslipidaemia[J]. Drugs,2001,1(12):1835.
  • 8Gonzalez F,Skoda RC,Kimura S,et al. Characterization of the common genetic defect in humans in debrisoquine metabolism [J].Nature,1988,31:442.
  • 9Mulder AB,Van Lijf HJ,Bon MA,et al. Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin [J]. Clin Pharmacol Ther,2001,0(6):546.
  • 10Geisel J. The efficacy of simvastatin is not influenced by CYP2D6 polymorphism[J]. Clin Pharmacol Ther ,2002,0(11):95.

共引文献69

同被引文献17

引证文献3

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部