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Aptamers Against Viral Hepatitis:from Rational Design to Practical Application 被引量:5

Aptamers Against Viral Hepatitis:from Rational Design to Practical Application
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摘要 Aptamers are short nucleic acids or peptides that strongly bind to a protein of interest and functionally inhibit a given target protein at the intracellular level. Besides high affinity and specificity, aptamers have several advantages over traditional antibodies. Hence, they have been broadly selected to develop antiviral agents for therapeutic applications against hepatitis B and C viruses (HBV, HCV). This review provides a summary of in vitro selection and characterization of aptamers against viral hepatitis, which is of practical significance in drug discovery. Aptamers are short nucleic acids or peptides that strongly bind to a protein of interest and functionally inhibit a given target protein at the intracellular level. Besides high affinity and specificity, aptamers have several advantages over traditional antibodies. Hence, they have been broadly selected to develop antiviral agents for therapeutic applications against hepatitis B and C viruses (HBV, HCV). This review provides a summary of in vitro selection and characterization of aptamers against viral hepatitis, which is of practical significance in drug discovery.
出处 《Virologica Sinica》 SCIE CAS CSCD 2008年第5期315-320,共6页 中国病毒学(英文版)
基金 Program of Chinese Academy of Sciences (0802021SA1)
关键词 Aptamers Hepatitis B viruses (HBV) Hepatitis C viruses (HCV) 病毒性肝炎 临床分析 治疗方法 抵抗力
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