摘要
本研究对脑肿瘤手术前后血浆内皮素－１含量变化进行了研究和分析。方法：采用均相放射免疫竞争方法直接测定３７例脑肿瘤患者和２４例对照血浆ＥＴ－１含量。结果：脑瘤患者浆ＥＴ－１含量为７１．０１４％ｐｇ／ｍｌ，比对照组５３．３５２ｐｇ／ｍｌ和标准值５０．８ｐｇ／ｍｌ高，有统计学意义。术后第二天血浆ＥＴ－１含量比术前和术后第八天低，术后第八天比术前血浆ＥＴ－１含量低，均有统计学差异．脑膜瘤、胶质瘤和垂体瘤患者术前血浆ＥＴ－１含量均比对照组高，不同病理类型的脑肿瘤患者术后血浆ＥＴ－１与术前比较均下降，但无显著性差异。结论：ＥＴ－１除参与脑肿瘤的发生、发展和分化过程外，还参与手术前后脑血流的调节。
Purpose:This article analysed the pre and post operative plasma endothelin1(ET1)level of patients with intracranial tumors.Method:The plasma ET1 concentration was measured in 37 patients with intracranial tumors and 24 controls using competitive radioimmunoassay.Result:The plasma ET1 Level of patients with intracranial tumors was 71.014pg/ml,which was significantly higher than that of control (53.352pg/ml).The preoperative plasma ET1 level was significantly higher than postoperative ET1,and ET1 of patients seven days after operation was statistically higher than that of one day after operation.Conclusion:Besides the effect of plasma ET1 on the pathophysiology of brain tumors,ET1 could also regulate the blood supply of brain.
关键词
内皮素
血浆
脑肿瘤
手术
Endothelin-1(ET1) Plasma Intracranial tumor
