摘要
我们根据ＣＤ４＋Ｔ细胞识别抗原位点的物理化学和生物学特征，设计了一个具有查找两亲性螺旋状结构（ａｍｐｈｉｐａｔｈｉｃｈｅｌｉｘｓｔｒｕｃｔｕｒｅ）肽段功能的计算机程序。用该程序对ＨＣＶ－１型病毒Ｃ、Ｅ（Ｅ１、Ｅ２／ＮＳ１）、ＮＳ５蛋白一级结构进行分析，发现这些蛋白区存在ＣＤ４＋Ｔ细胞识别位点。此结果支持了ＣＤ４＋Ｔ细胞对ＨＣＶＣ，Ｅ，ＮＳ５区可发生增殖反应的结论。提示该程序可作为一种预测ＣＤ４＋Ｔ细胞识别ＨＣＶ抗原位点的方法。
A computer programme with the function of finding amphipathic helix structure was written on the basis of physical, chemical and biological characters of antigen sites that can stimulate CD 4 + T cell.Analysis of the hepatitis C virus (HCV 1) primary sequence of C, E, and NS5 regions showed that the CD 4 + T cell antigen sites could be found in these regions. The findings were in agreement with the conclusion that C, E and NS5 proteins could activate CD 4 + T cell in HCV patients. It indicates that our programme can be used to predict the CD 4 + T cell antigen sites on HCV proteins.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
1997年第3期18-22,13,共6页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金
