摘要
为了解干扰素治疗后干扰素中和抗体的产生及对干扰素疗效的影响,用中和生物法检测了27例乙型肝炎患者干扰素治疗前后血中干扰索中和抗体。27例患者接受干扰素治疗后,15例血中检出中和抗体(55.6%;15/27)。在抗体阳性的15例患者中,治疗结束时,4例血中 HBVDNA 阴转(26.7%,4/15),在抗体阴性的12例患者中,10例 HBV DNA 阴转(83.3%;10/12),二者比较 P<0.01。中和抗体滴度≥800者,HBV DNA 阴转率为9%(1/11),抗体滴度<800者,HBVDNA 阴转率为75%(3/4,P<0.05)。表明干扰素中和抗体是影响干扰素疗效的主要因素之一,滴度越高影响越大。
In order to study the affection of neutralizing antibody on the therapeutic effect of IFNα -2b,NBA was used to detect the neutralizing antibody to against IFN in the sera from 27 patients with chronic hepatitis B.The results indicated that neutralizing antibody against IFN was present in 15 of 27 patients who had been treated with IFNα-2b,and the overall frequency of neutralizing antibody was 55.6%(15/27).At the end of IFN therapy,HBV DNA was undetectable in 4 of the 15 patients(4/15, 26.7%)with neutralizing antibody.By contrast.HBV DNA became undetectable in 10 of the 12 patients (10/12,83.3 % ) without neutralizing antibody (P<0.05).In patients with high titer (≥800) of neu- tralizing antibody,the clearanse rate of HBV DNA was 9% (1/11),whereas,among those with neutraliz- ing antibody below 800,the clearanse rate of HBV DNA was 75% (3/4)at the end of IFN therapy (P< 0.05).It is concluded that the neutralizing antibody was one of the main factors affecting the response to interferon therapy.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
1997年第4期197-199,共3页
Chinese Journal of Infectious Diseases
