摘要
目的：观察神经性毒剂梭曼中毒导致犬心电图和心肌酶的变化及新型抗毒剂宾赛克嗪（benthiactzine）的解救作用。方法：健康成年雄性杂种犬7只,体重12-15kg。在麻醉状态下,每次肌肉注射1/3LD梭曼（1LD=10μg/kg）,每10min追加1次的累积染毒;以平均动脉压降至40-45mmHg（1mmHg=0.133kPa）为循环衰竭标准。观察在梭曼染毒前后及宾赛克嗪救治后犬的血压、心率、心电图和心肌酶的变化。结果：染毒后诱发犬进行性循环衰竭,心率减慢,房室传导阻滞,部分P波消失,出现室性逸搏,结性心律;T波高耸,波峰尖锐。血液中肌酸磷酸激酸同工酶（CK-MB）和乳酸脱氢酶（LDH）水平显著增加（P〈0.05）,表明梭曼染毒导致犬循环衰竭发生心脏受损明显。宾赛克嗪0.1mg/kg静脉注射,57.1%的犬在3-5min恢复窦性心律,心率增加,房室传导阻滞消失,心电图T波可基本恢复,但血液中CK-MB和LDH在救治后无显著恢复。结论：胆碱酯酶抑制剂类毒物梭曼中毒可引起严重心律失常,宾赛克嗪可给予有效的救治。
AIM： To investigate the changes of electrocardiogram（ECG）, LDH and CK-MB caused by soman, and the therapeutic effects of benthiactzine. METHODS： 7 healthy male dogs, weighing 12-15 kg, were given intramuscularly 1/3 LD soman （1 LD = 10/lg/kg） per ten minutes. The mean blood pressure lower than 40 - 45 mm Hg was defined as circulatory failure. The changes of ECG, heart rate, blood pressure, LDH and CK-MB were recorded either before and after soma was given or after benthiactzine was given. RESULTS： It was observed that decreased heart rate, A-V block, high and sharp T wave with or without P wave in ECG of dogs after soma was given. Meanwhile, the levels of CK-MB and LDH were increased significantly （ P 〈 0.05 ）. The treatment of benthiactzine made the ECG recovery normal, but CK-MB and LDH did not obviously change. CONCLUSION： The cholinesterase inhibitor soman leads to serious arrhythmia which can be remedied by benthiactzine.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2008年第8期886-890,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
梭曼
宾赛克嗪
循环衰竭
心电图
犬
soman
benthiactzine
circulatory failure
ECG
dog
