摘要
目的:探讨肺肉瘤样癌(Lung sarcomatoid carcinoma,LSC)的特征及影响预后的因素。方法:回顾性分析天津医科大学附属肿瘤医院1985年9月至2007年7月收治的47例肺肉瘤样癌患者临床资料。其中行手术为主综合治疗44例,非手术治疗3例。分别对性别、年龄、吸烟史、肿瘤大小、pTNM分期和组织学类型等因素进行预后分析。Kaplan-Meier法计算生存率,Log-rank法进行生存率显著性检验,Cox比例风险回归模型进行单因素和多因素分析。结果:全组患者临床特征与其他类型肺癌相似,1、3和5年总生存率分别为59.6%、27.7%和8.5%。单因素分析显示,年龄(P=0.006)、肿瘤大小(P=0.023)、pTNM分期(P=0.000)、T分期(P=0.001)、有无淋巴结转移(P=0.002)、M分期(P=0.000)和组织学类型(P=0.045)是影响预后的因素。多因素分析则显示,年龄(P=0.002)、T分期(P=0.011)和M分期(P=0.004)是影响预后的独立因素。结论:肺肉瘤样癌的诊断主要依靠术后病理,缺乏特异性临床表征,影响其预后的因素主要为年龄、T分期和M分期。
Objective： To investigate the characteristics of lung sarcomatoid carcinoma （LSC） and to analyze the corresponding prognostic factors. Methods： We retrospectively reviewed the clinical data from 47 patients with LSC seen in our hospital from September 1985 to July 2007. Forty-four of them underwent surgery and the remaining 3 patients received non-surgical therapy. Gender, age, smoking history, tumor size, p-TNM stage, and histological type were analyzed. The survival rate was calculated by Kaplan-Meier method and log-rank test was used to compare the survival rates. Univariate and multivariate factors for survival were analyzed by Cox proportional hazards regression model. Results： The clinical characteristics of LSC were similar to those of other types of lung cancer. The overall 1-, 3-, and 5-year survival rates were 59.6%, 27.7% and 8.5%, respectively. Cox univariate analysis revealed that age, tumor size, p-TNM stage, T stage, lymph node metastasis, M stage and histological type were prognostic factors. Cox multivariate analysis found that age, T stage, and M stage were independent prognostic factors for LSC. Conclusion： There is no specificity in the clinical characteristics of LSC and its successful diagnosis depends on postoperative pathological analysis. Age, T and M stage are the crucial prognostic factors for LSC.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2008年第18期1045-1049,共5页
Chinese Journal of Clinical Oncology
关键词
肉瘤样癌
临床特征
预后因素
非小细胞肺癌
Sarcomatoid carcinoma
Clinical characteristics
Prognostic factors
NSCLC
