摘要
目的:对比传统治疗与加用药物治疗对外伤性鼓膜穿孔愈合的影响,研究重组人表皮生长因子(rhEGF)对外伤性鼓膜穿孔愈合的促进作用。方法:将90例外伤性鼓膜穿孔患者随机分成2组:传统治疗组给予消炎药物治疗及避免外耳道进水、鼻腔滴药的传统治疗方法;rhEGF治疗组给予传统治疗的基础上,加用rhEGF棉片贴补治疗。观察2组患者鼓膜穿孔愈合情况和听力提高程度。结果:rhEGF治疗组58例患者穿孔均愈合,愈合率100%,平均愈合时间为5.3d;传统治疗组32例中有25例愈合,7例穿孔未愈合,愈合率78%,平均愈合时间为28.4d。rhEGF治疗组鼓膜穿孔愈合时间较传统治疗组明显缩短,差异有统计学意义(P<0.01);2组愈合率有显著性差异(P<0.05)。结论:加用rhEGF治疗外伤性鼓膜穿孔能明显缩短鼓膜穿孔愈合时间,提高鼓膜穿孔愈合率。
OBJECTIVE： To compare the healing effect of traditional therapy versus the traditional therapy in combination with additional externally applied agent on the traumatic tympanic membrane perforation with a focus on the effect of recombinant human epidermal growth factor （rhEGF） in promoting healing of tympanic membrane perforation. METHODS： A total of 90 patients with traumatic tympanic membrane perforation were randomly divided into two groups： one group received traditional therapy in which the anti - inflammatory drug was given plus nasal administration with water not allowed entering in the external acoustic meatus; another group was treated with traditional therapy plus rhEGF cotton applied externally. The healing of the tympanic membrane perforation and the auditory acuity improvement in two groups were monitored. RESULTS： In rhEGF group （58 cases）, the cure rate reached 100%, with an average healing time of 5.3 days; Of the 32 cases in the traditional therapy group, 7 were not failed, and 25 （78%） healed, with an average healing time of 28.4 days. The healing time of tympanic membrane perforation in rhEGF group was significantly shorter than in traditional group, showing significant difference （P 〈 0.01） . The healing rates in two groups were also significantly different （P〈0.05） . CONCLUSION： The additional external application of rhEGF can significantly shorten the healing time for tympanic membrane perforation meanwhile increasing the healing rate of the tympanic membrane perforation.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第29期2292-2293,共2页
China Pharmacy
关键词
重组人表皮生长因子
外伤性鼓膜穿孔
临床研究
Recombinant human epidermal growth factor
Traumatic perforation of ear drum
Clinical study
