摘要
目的:观察L-抗坏血酸-2-磷酸酯镁(VC-PMG)霜外用治疗黄褐斑的疗效及安全性。方法:外用10%VC-PMG霜治疗25例黄褐斑患者,并用MicroskinⅡ多功能偏振光皮肤镜图像分析系统对治疗前、后黄褐斑皮损进行客观测量及评价。结果:经10%VC-PMG霜外用治疗各型黄褐斑16周后,平均有效率为20%,其中单一蝶形皮损效果最佳,有效率为44.4%,同一患者治疗前后对色素斑L*、a*、b*值检测结果显示差异有统计学意义(P<0.05)。在临床治疗观察的整个过程中未见明显不良反应发生。结论:局部外用10%VC-PMG霜可以减少黄褐斑患者皮损部位的黑素含量、毛细血管扩张程度,以及减轻黄色素和脂色素以改善色素斑,达到治疗黄褐斑的目的。
Objective： To evaluate the efficacy and safety of magnesium-L-ascorbyl-2-phosphate（VC-PMG） cream for the treatment of patients with melasma. Methods： Twenty five patients with melasma were topically treated with 10% VC-PMG cream twice daily for 16 weeks. The pigmentation of skin lesions was measured by a dermoscope, namely Microskin Ⅱ multifunction system with polarizing microscope and digital image. Results： The average effective rate was 48% 16 weeks later, and which reached 88.9% in the patients with skin lesions of butterfly distribution. In the same individuals, the values of L^＊, a^＊, b^＊ and ITA° showed statistical differences（P〈 0.05） before and after treatment. No adverse effect was found during the study. Conclusions： Topical 10% VC-PMG cream is effective and safe in melasma, without obvious side effect during the period of observation. The cream can reduce the amount of melanin in the lesions, yellow pigment and lipoehrome, and relieve the extent of telangiectasis in pigmented areas.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2008年第10期681-683,共3页
Journal of Clinical Dermatology
