摘要
观察百日咳菌液诱导的感染性脑水肿不同时间大鼠脑含水量和伊文思蓝（ＥＢ）含量的变化，以及Ｎｉｍｏｄｉｐｉｎｅ对感染性脑水肿脑含水量和ＥＢ含量的影响。结果表明：感染性脑水肿在注菌后３０ｍｉｎ，脑含水量和ＥＢ含量已明显升高；应用Ｎｉｍｏｄｉｐｉｎｅ治疗后，脑组织水份含量和ＥＢ含量显著降低，脑水肿明显减轻。
The changes of brain water content and Evan blue(EB) were investigated on the model of infection brain edema induced by Pertussis Bacilli(PB) in 72 rats. Nimodipine was admenistred to show its effect on the PB induced brain edema. The experiment results showed that the water content and EB content in the PB group were significantly increased than those normal group and normal saline group at 30min, 4 hours and 24 hours after the injection of PB (P<0.05). Nimodipine could significantly reduce brain water content and EB content, so that brain edema was attenuated. It indicates that nimodipine showed advantage to treatment of PB brain edema.
出处
《湖南医科大学学报》
CSCD
1997年第5期393-396,共4页
Bulletin of Hunan Medical University
