摘要
目的:改善盐酸甲氯芬酯胶囊的稳定性。方法:在不改变盐酸甲氯芬酯胶囊规格的前提下,筛选适宜的辅料及工艺,制成的胶囊剂以外观性状、含量、有关物质和溶出度为指标,考察其稳定性。结果:改进后的盐酸甲氯芬酯胶囊质量稳定,其各项指标符合质量标准。结论:本方法较好地解决了盐酸甲氯芬酯胶囊的吸湿性问题,提高了产品稳定性。
Objective：To improve the stability of meclofenoxate hydrochloride capsules. Methods： Under the premise of unchanged drug specifications, suitable excipients and preparing process were screened, the stability of pre- pared capsules was studied by appearance, content, related substances and dissolubility. Results： After being improved, the quality of meclofenoxate hydrochloride capsules was stable, its various indexes conformed to the quality standard. Conclusion： The method may solve the hygroscopicity of meclofenoxate hydrochloride capsules, and its stability can be improved.
出处
《上海医药》
CAS
2008年第10期461-463,共3页
Shanghai Medical & Pharmaceutical Journal
关键词
盐酸甲氯芬酯胶囊
乙基纤维素
稳定性
meclofenoxate hydrochloride capsules
ethyl cellulose
stability
