1[2]Lequesne M.Indices of severity and disease activity for osteoarthritis[J]. Semin Arthritis Rheum,1991,20(6 Suppl 2):48.
2[4]Waikakul S,Waikakul W.A post marketing survey on the side-effects of Loxoprofen[J]. J Med Assoc Thai,1999,82(7):721.
3Choo KS, Kim IW,Jung JK, et al. Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC- UV detection method[J]. J Pharm Biomed Anal ,2001,25(3 - 4) :639 - 650.
4Kim IW, Choo KS, Han TG, et al. Decreased oral bioavailability of loxoprofen at second administration in htmaan subjects[J]. Int J Clin Pharmacol Ther ,2000,38( 1 ) : 10 - 14.
5Hirai T, Matsumoto S, Kishi I. Simultaneous analyds of several nonsteroidal anti-inflammatory drugs hn human urine by high-performance liquid chromatography with normal solid-phase extraction[J].J Chromatogr B Biomed Sci Appl, 1997,692 (2) : 375 - 388.
6Kco TS, Kim DH, Ahn SH, a al. Comparison of phannacokinetics of loxoprofen and its active metabolites after an intravenous,intramuscular, and oral administration of loxopmfen in rats: evidence for extrahepatic metabolism[J]. J Pharm Sci, 2005,94(10) :2 187-2 197.
7Kim IW, Chung SJ, Shim CK. Altered metabolism of orally administration of loxoprofen for three consecutive days followed by a sevenday washout[J]. J Pharm Sci, 2002,91(4):973 -979.
8Cheo KS, Kim IW, Jung JK, et al. Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method [ J ]. J Pharm Biomed Anal, 2001,2,5(3 - 4) :639 - 650.
9RJendeau D, Salem M, Styhler A, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2[J]. Bioorg Med Chem Lett ,2004,35(23): 1 201- 1 203.
10Matsuda K,Tanaka Y, Ushiyama S, et al. Inhibition of prostaglandin synthesis by sodium 2-[ 4-( 2-oxocyclopentylmethyl ) phenyl ] propionate dihydrate (CS-600), a new anti-inflammatory drug, and its active metabolite in vitro and in vivo [ J ]. Biochem Pharmacol,1984,33(15) :2 473 - 2 478.
