摘要
目的:探讨手术前后前列腺素E_2(PGE_2)的动态变化在胃癌治疗和预后中的价值。方法:测定31例胃癌患者和30例正常对照者手术前后的PGE_2、自然杀伤NK细胞活性和T淋巴细胞亚群的动态变化。结果:胃癌患者术前PGE_2较正常对照组明显升高,且随病程进展逐渐升高。NK细胞活性、CD_3^+、CD_4^+及CD_4^+/CD_8^+明显降低。肿瘤组织中PGE_2含量高于正常组织,切除肿瘤后PGE_2逐渐降至正常。而NK细胞活性、CD_3^+、CD_4^+及CD_4^+/CD_8^+逐渐增高,术后4～6周可恢复正常水平。结论:测定胃癌患者术前后PGE_2可为临床治疗、评价手术疗效和估计预后提供客观指标。
In order to investigate pre- and postoperative changes of prostaglandin E2 (PGE2) and cellular immune function in patients with gastric cancer, T lymphocyte subsets, natural killer cell activity (NKCA) and PGE2 in peripheral blood of 31 patients with gastric cancer (GC) and 30 controls were determined using APAAP method, LDH release method and radioimmunoassay respectively. The results showed: 1) the cellular immune function of GC patients before operation was suppressed, CD4+/CD+8 ratio and NKCA were obviously decreased; 2) Preoperative peripheral blood PGE2 in the patients was significantly increased in comparison to controls and had a significant negative correlation with CD4+/CD+8 ratio and NKCA respectively, suggesting that PGE2 is one of the factors responsible for depressed cellular immune function of cancer patients. 3) Peripheral blood PGE2 in the patients was gradually declined to normal level after operation. Moreover, PGE2 in tumor tissue was markedly higher than that in normal tissue, implying the tumor may be the major source of peripheral blood PGE2. The level of peripheral blood PGE2 might reflect the size of tumor; 4)Dynamic determination of peripheral blood PGE2 would be great valuable in evaluating the cellular immune state and effects of operation and prognosis of the patients with gastric cancer.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1997年第6期338-339,共2页
Chinese Journal of Experimental Surgery
关键词
前列腺素E2
胃肿瘤
外科手术
预后
Stomach neoplasm
Prostaglandin E2 Treatment and prognosis.
