摘要
采用镇静、催眠及抗惊厥等方法研究脑乐静口服液的神经药理作用。结果表明：脑乐静口服液（４、８、１６ｇｋｇ－１，ｉｇ，ｑｄ×７ｄ）能延长戊巴比妥钠诱导的小鼠睡眠时间；对抗士的宁诱发的小鼠惊厥，抑制小鼠的自发活动；但对小鼠最大电休克发作及爬杆活动无明显影响。此外，小鼠ｉｇ给药未能测出此药的ＬＤ５０，１日最大耐受量是５４０ｇｋｇ－１。提示脑乐静口服液毒性小，有一定的镇静、催眠及抗惊厥作用。
The effects of naoluojin oral liquid on sedation, hypnosis and anticonvulsion in mice were investigated. The reswlts showed that this solution at the doses of 4、8、16 g·kg -1 (ig, qd×7 d) could prolong the sleeping time induced by pentobarbital sodium, antagonize to the convulsion induced by strychinine and inhibit the spontaneous moter activity in mice respectively. However, it didnt significantly influence the maximal electroshock seizure (MES) and sports of climbing holder. These data suggested that the liquid had the action of sedation, hypnosis and anticonvulsion.
出处
《安徽医科大学学报》
CAS
1997年第5期532-533,共2页
Acta Universitatis Medicinalis Anhui
关键词
脑乐静口服液
小鼠
中成药
药理作用
MeSH sedatives and hypnotics/pharmacology
anticonvulsants/pharmacology
animals, experiment naoluojin oral liquid
mice
