摘要
目前普遍认为炎症性肠病是在遗传背景的前提下,环境因素(如感染等)导致肠道免疫紊乱而发病.近年来,防御素(defensin)家族在先天性防御体系中的作用日益受到研究学者的重视.本文就防御素的种类、分布、基因表达调控、其抗微生物作用,以及其与炎症性肠病的关系和应用前景作一综述.
It is commonly considered that genetic and environmental factors （e.g. infection） contribute to the occurrence of inflammatory bowel disease （IBD）. In recent years, defensin family was attracting great attention because of its role in the innate defense system. In this paper, we review the defensin’s types, distribution, gene expression regulation, antimicrobial effects and relationships with IBD as well as its future application prospects.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第28期3204-3207,共4页
World Chinese Journal of Digestology
关键词
防御素
炎症性肠病
先天免疫
鉴别诊断
克罗恩病
溃疡性结肠炎
Defensin,Inflammatory bowel disease,Innate immune,Differential,diagnosis Crohn＇s dis-ease,Ulcerative colitis
