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红景天提取物对纤维肉瘤细胞T241增殖功能的影响及抑瘤作用的初步研究 被引量:6

Rhodiola sachalinensis Suppresses T241 Fibrosarcoma Tumor Cells Proliferation in vitro and Growth in vivo
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摘要 目的:通过体内外实验研究红景天提取物对T241肿瘤细胞增殖的影响。方法:检测不同浓度红景天醇提取物对T241肿瘤细胞增殖及细胞存活的影响;C57BL6/J荷瘤小鼠分为红景天组及实验对照组,观察红景天灌胃处理对荷瘤小鼠肿瘤生长的作用,计算两组肿瘤生长抑制率。结果:红景天醇提取物抑制T241细胞增殖呈浓度依赖性,且浓度在在50μg/ml至250μg/ml之间时实验组与对照组相比细胞存活率没有显著差异。荷瘤小鼠在红景天灌胃21 d后,与对照组相比,红景天组抑瘤率达到了70.9%。结论:红景天在体内外实验均能有效抑制T241纤维肉瘤细胞的增殖,且未发现明显细胞毒作用。 Objective: To study the anticancer activity of Rhodiola sachalinensis in vitro and in vivo experiments. Methods: The effect of Rhodiola sachalinensis extracts at various concentrations on T241 fibrosarcoma cells proliferation and cytotoxic potential were measured. We divided T241 fibrosarcoma-bearing C57B16/J mice into two groups, the tumor inhibition rate were observed. Results: Rhodiola sachalinensis extracts inhibited T241 tumor cells growth in a dose-dependent manner. The concentrations of Rhodiola sachalinens/s extracts from 50μg/ml to 250μg/ml did not reduced the survival rate of T241 tumor ceils. The daily administration of Rhodiola sachalinensis resulted in a significant suppression of the growth of primary tumors, compared to control group, tumor inhibition rate in Rhodiola sachalinensis group reached 70. 9%. Conclusion: Rhodiola sachalinensis can inhibit T241 tumor cells growth and does not cause a direct cytotoxicity against tumor cells in vitro and in vivo.
出处 《中药材》 CAS CSCD 北大核心 2008年第9期1377-1380,共4页 Journal of Chinese Medicinal Materials
关键词 红景天 纤维肉瘤细胞 抑瘤作用 Rhodiola sachalinensis T241 fibrosarcoma cell Anticancer activity
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