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VEGF在子宫内膜异位症中的表达及其意义 被引量:2

Expression and Significance of VEGF in Endometriosis
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摘要 目的观察血管内皮生长因子(VEGF)在子宫内膜异位症(EMS)中的表达并探讨其在EMS发病机制中的作用。方法利用免疫组化法检测VEGF在30例EMS的异位内膜及在位内膜组织、30例正常子宫内膜组织中的表达。结果VEGF在异位内膜的表达显著高于在位内膜和正常子宫内膜(P<0.05)。VEGF在EMS在位内膜的表达显著高于正常子宫内膜(P<0.05)。结论VEGF在EMS的发生、发展中起重要作用。 Objective To observe the expression of vascular endothelial growth factor(VEGF) in endometriosis,and to explore its possible role in the pathogenesis of endometriosis.Methods The expression of VEGF in 30 normal endometrium,30 ectopic endometrium and eutopic endometrium were detected by immunohistochemistry,and the data was analyzed with SPSS11.0 statistical software.Results The expression level of VEGF in the ectopic endometriotic tissues was significantly higher than those in the eutopic endometrium and nomal endometrium(P〈0.05),and the expression level of VEGF in the eutopic endometrium was significantly higher than that in nomal endometrium(P〈0.05).Conclusions VEGF may contribute to the pathogenesis of endometriosis.
出处 《咸宁学院学报(医学版)》 2008年第4期298-300,共3页 Journal of Xianning Univarsity(medical Sciences)
关键词 血管内皮生长因子 子宫内膜异位症 免疫组织化学 表达 Vascular endothelial growth factor Endometriosis Immunohistochemistry Expression
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同被引文献30

  • 1沈育红,唐中园,喇端端.VEGF-165在异位、在位和正常子宫内膜中的表达[J].微循环技术杂志(临床与实验),2004,8(5):304-306. 被引量:3
  • 2朱慧莉,黄薇.VEGF在子宫内膜异位症发病机制中的作用[J].现代妇产科进展,2006,15(9):678-680. 被引量:8
  • 3蒋红清,李亚里,陈浩,汪淑娟,邹杰.血管内皮生长因子C和受体3在子宫内膜异位症的表达及意义[J].军医进修学院学报,2007,28(2):99-101. 被引量:4
  • 4彭茜,朱瑾.子宫内膜异位症与免疫[J].中国免疫学杂志,2007,23(5):474-478. 被引量:13
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