摘要
目的:考察胰岛素注射液在输液过程中的浓度变化情况,测定输液瓶对胰岛素的吸附量,以指导临床合理操作。方法:模拟临床胰岛素配液以及输注操作过程,实验分为18组:5%葡萄糖组(玻璃瓶组和塑料瓶组)、10%葡萄糖组(玻璃瓶组和塑料瓶组)和氯化钠组(玻璃瓶组和塑料瓶组),各组又按操作的不同分为振摇组、非振摇组和吸附组,采用紫外分光光度法测定胰岛素浓度。振摇组、非振摇组流速为50滴/min,每输注50mL液体取样测定胰岛素浓度。吸附组每隔10min轻轻振摇1次,并取液测定浓度。结果:在不同材质输液瓶之间、不同浓度的葡萄糖之间胰岛素浓度变化比较,差异无显著性;在不同种类溶媒中变化趋势不同:在氯化钠注射液中,胰岛素浓度在滴注50mL左右出现极大值,而后逐渐降低达到平稳状态;在葡萄糖注射液中,胰岛素浓度先升高,随后胰岛素浓度降低,在滴注350mL左右浓度又出现极大值。非振摇组在输注期间普遍出现胰岛素浓度骤然升高现象,而振摇组胰岛素浓度变化较为平稳;不同材质和装有不同溶媒的输液瓶对胰岛素的吸附趋势类似,但塑料瓶对胰岛素的吸附量大于玻璃瓶,装有氯化钠的输液瓶大于葡萄糖输液瓶,10%葡萄糖输液瓶大于5%葡萄糖输液瓶。结论:在胰岛素输液过程中,可通过对输液瓶每隔10min振摇一次,以有效避免在输液期间出现的胰岛素浓度升高现象,防止其引起的低血糖现象的出现;临床操作时还应考虑到药物的吸附损失。
OBJECTIVE To observe the changes of insulin concentration in clinical transfusion and the adsorption quantity in different infusion sets. METHODS In the experiment, the same processes of mixing insulin and its transfusion as in the clinical treatment were imitated. The experiment was divided into 18 groups： isotonic Na chloride （glass bottles and plastic bottles）, 5% glucose injection （glass bottles and plastic bottles） and 10% glucose injection （glass bottles and plastic bottles）, each group was further divided into another 3 groups according to the different operation： The first group was shaken regularly in the process of transfusion the second group was not shaken at all let it transfused naturally. Insulin concentration of the sample taken after each 50 mL of the mixed solution droped was monitored by UV Spectrophotometry. The third group was shaken every 10 minutes and to detect the concentration of insulin. RESULTS The insulin concentration of the glass bottles groups, compared with that of the plastic bottle groups had no obvious differences, but there were some difference between the different injections. The insulin concentration of the natural dropping groups increased suddenly, but became stable when the transfusion set was shaken properly. The adsorption curve was similar between different infusion sets and different menstruum. The adsorption quantity of the plastic bottle was more than glass bottles isotonic Na chloride was more than the glucose CONCLUSION The proper shaking of the transfusion set in the process of transfusion of insulin can effectually avoid the increase of insulin concentration in the procedure of transfusion to prevent the hypoglycemia.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第19期1634-1638,共5页
Chinese Journal of Hospital Pharmacy
基金
河北省科技攻关(编号:05276101D-88
42761220)
河北省卫生厅(编号:05015)
河北大学人才引进(编号:y2004039)
河北大学自然科学基金(编号:2005Y08)资助项目
关键词
胰岛素
输液过程
浓度变化规律
吸附量
护理
insulin
transfusion process
regularity of concentration changes
adsorption quantity
nurse
