摘要
目的:比较腹腔镜阑尾切除术与开腹阑尾切除术对腹腔局部免疫功能的影响。方法:检测62例腹腔镜阑尾切除术患者(A组)和66例开腹阑尾切除术患者(B组)腹腔中性粒细胞吞噬功能、巨噬细胞产生TNFα生物学活性、腹腔T细胞亚群CD4+/CD8+的比值,并采用T检验比较两组各项指标的差异。结果:B组和A组腹腔pH值分别为7.13和7.39;中性粒细胞化学发光峰值为分别为98和102;L929细胞OD570值分别为0.183和0.152;CD4+/CD8+比值分别为0.53和0.57。除CD4+/CD8+比值外,其余三项指标的差异均有显著性。结论:与腹腔镜阑尾切除术比较,开腹阑尾切除术对腹腔局部免疫特别是细胞免疫有明显的抑制效应,对巨噬细胞功能的影响尤为显著。
Objective ：To compare the influence of laparoscopic and open ecphyadectom on the immune function of the local peritoneal cavity. Methods：Determination of the phagocytic function of neutrophils, the biological viability of TNF α produced by macrophages and the T lymphocytes subsets CD4＋/CD8＋ ratio of the peritoneal cavity in a group of 62 cases who underwent laparoscopic ecphyadectom and in another group of 66 cases who underwent open ecphyadectom. We used T test to compare the difference of these 4 indexes between both groups. Results：The group B and group A, The mean peak value of chemiluminescence was 98 and 102 respectively; the mean OD570 of L929 Cells was 0.183 and 0.152 respectively; and the CD4＋/CD8＋ ratio was 0.53 and 0.57 respectively. Except for the CD4＋/CD8＋ ratio, the difference of the other 3 indexes between both groups were of significance. Conclusion：Compared to laparoscopic surgery, open eephyadeetom has obvious depressive effects on the immune functions particularly cell-mediated immune function of the local peritoneal cavity.
出处
《中国医药导报》
CAS
2008年第28期33-34,共2页
China Medical Herald
关键词
阑尾切除术
腹腔镜手术
开腹手术
免疫功能
Ecphyadectom
Laparoscopic ecphyadectom
Open ecphyadectom
Immune function
