摘要
目的:探讨彩色图形视觉诱发电位(color pattern reversal visual evoked potential,CPR-VEP)在不同时间频率时对原发性青光眼诊断的敏感性,寻找最佳时间频率参数及色彩参数。方法:采用法国M啨trovision公司生产的Vision Monitor视觉电生理仪对41例(70眼)青光眼患者(青光眼组)和13例(26眼)正常人(正常对照组)在不同时间频率(1,2,4,8,16,32 Hz)及色彩刺激(黑/白、红/绿、蓝/黄)下记录CPR-VEP的变化,比较P100的波幅值。结果:(1)正常对照组黑/白刺激下CPR-VEP P100波幅-时间频率曲线的波幅值随着时间频率的增加而下降明显;红/绿及蓝/黄刺激下2 Hz及8 Hz处波幅增高。(2)青光眼组CPR-VEP P100波幅-时间频率曲线的波幅值随着时间频率的增加而下降明显,但在8 Hz处波幅明显增高;除32 Hz及红/绿刺激下的1 Hz外,不同时间频率的色彩刺激下CPR-VEP P100与Hum-phrey视野平均缺损(mean defect,MD)值呈显著相关关系,以8 Hz的频率及蓝/黄刺激下的2 Hz和16 Hz相关性较大。(3)青光眼组与正常对照组P100波幅具有差异,3种色彩刺激在8 Hz处差别大。结论:CPR-VEP P100的波幅变化在一定程度上能客观反映青光眼患者的视功能损害,3种色彩刺激在8 Hz及蓝/黄刺激在2 Hz和16 Hz处具有较高的价值。
Objective To investigate the changes of color pattern reversal visual evoked potential （ CPR-VEP ） of primary glaucoma using different temporal frequencies, and to search for the best temporal frequency parameters and color parameters. Methods Vision Monitor visual electrophysiograph （ Metrovision, France ） was used to record CPR-VEP at different temporal frequencies （ 1 , 2, 4, 8, 16, and 32 Hz） and different color stimulations （black / white, red / green, blue / yellow） in 4t cases （ 70 eyes） with primary glaucoma （ glaucoma group） and 13 normal subjects （26 eyes） （ normal control group）. P100 wave amplitudes were compared. Results （ 1 ） In the normal control group, P100 amplitudes declined while the temporal frequency of black / white stimulation was increasing, but they had peaks at 2 Hz and 8 Hz red / green stimulation and blue / yellow stimulation. （2） In the glaucoma group, CPR-VEP P100 declined while temporal frequency was increasing under 3 color stimulations, but had a peak at 8 Hz. At 2 Hz - 16 Hz, P100 amplitudes were related with the mean defect of Humphrey visual field, especially with all 3 color stimulatins at 8 Hz and with blue / yellow stimulation at 2 Hz and 1 6 Hz. （3） Pl00 amplitude was most different under the 3 color stimulations between the 2 groups at 8 Hz. Conclusion amplitude can objectively reflect the glaucoma visual function damage The changes of CPR-VEP P100 CPR-VEP P100 amplitude has certain value in studying glaucoma under different color stimulations （black / white, red / green, blue / yellow ） at 8 Hz, and blue / yellow stimulation at 2 Hz and 1 6 Hz.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2008年第9期821-825,共5页
Journal of Central South University ：Medical Science
基金
湖南省卫生厅科研基金(B2006-017)~~
关键词
原发性青光眼
彩色图形视觉诱发电位
时间频率
波幅
primary glaucoma
color pattern reversal visual evoked potential
temporal frequency
amplitude
