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microRNA与肿瘤侵袭转移 被引量：5

MicroRNA and Tumor Invasion and Metastasis
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摘要 microRNA（miRNA）是一类长度为17—25nt的单链非编码RNA，通过与靶基因mRNA互补位点的结合在转录后水平调控靶基因的表达。miRNA作为调控基因表达的重要分子在肿瘤侵袭转移中的作用越来越受到重视，阐明miRNA在肿瘤侵袭和转移中的作用机制具有重要的理论意义，同时也可以为肿瘤的诊断和治疗提供新方法。文章综述了miRNA在鼻咽癌、乳腺癌、肺癌、肝癌、结直肠癌和前列腺癌侵袭转移过程中作用机制的研究进展。 microRNA （miRNA） indicates 17 - 25 nucleotides （nt） single-stranded non-coding small RNAs, which mediate post-transcriptional repression of mRNA targets specifically, miRNA plays an important role in invasion and metastasis of tumors and provide new methods for tumor diagnosis and treatment. It is of great theoretical significance to elucidate underlying mechanism of miRNA in invasion and metastasis of cancer. This review introduces the progress of understanding the mechanism of miRNA in invasion and metastasis of tumors, including nasopharyngeal carcinomas, breast cancer, lung cancer, hepatocellular carcinoma, colorectal cancer and prostate cancer.
作者 李娜 吴永革 郑晓飞
机构地区 军事医学科学院放射与辐射医学研究所 吉林大学生命科学学院
出处 《医学分子生物学杂志》 CAS CSCD 2008年第5期428-431,共4页 Journal of Medical Molecular Biology
基金 国家重点基础研究发展规划项目(973计划)(No.2002CB513103) 国家高技术研究发展计划资助项目(863计划)(No.2006AA02Z127)~~
关键词 MICRORNA 肿瘤 侵袭 转移 microRNA cancer invasion metastasis
分类号 Q752 [生物学—分子生物学]
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参考文献1

二级参考文献51

  • 1Pillai RS. MicroRNA function: multiple mechanisms for a tiny RNA? RNA 2005; 11:1753-1761.
  • 2Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005; 309:1519-1524.
  • 3Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
  • 4Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr Opin Drug Discov Dev 2005, 8:557-566.
  • 5Brennecke J, Stark A, Russell R.B, Cohen SM. Principles of microRNA-target recognition. PLoS Biol.2005; 3:e85.
  • 6Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122:6-7.
  • 7Chen CZ, Li L, Lodish HF, Bartel DE MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83- 86.
  • 8Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2006; 94:776-780.
  • 9Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev 2006; 16:4-9.
  • 10Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.

共引文献209

同被引文献36

  • 1JEMAL A, BRAY F, CENTER M M, et al. Global cancer statistics [J]. CA Cancer J Clin ,2011 ,61 :69-90.
  • 2LEE R C, FEINBAUM R L, AMBROS V. Thee. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [J J. Cell, 1993,75: 843- 854.
  • 3REINHART B J , SLACK F J, BASSON M, et al. The 21- nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J] . Nature, 2000 ,403 : 90 1-906.
  • 4LIU W , MAO S Y , ZHU W Y. Impact of tiny miRNAs on cancers [J]. World J Gastroenterol, 2007 , 13 ( 4 ) : 497- 502.
  • 5DENLI AM, TOPS B B, PLASTERK R H, et al. Processing of primary micro RNAs by the microprocessor complex [J]. Nature ,2004 ,432(7014) :231-235.
  • 6CARTHE R W. Gene regulation by microRNAs [J] . Curr opin Genet Dev,2006,16(2) :203-208.
  • 7FRIEDMAN R C, F ARH K K, BURGE C B, et al. Mostmammalian mRNAs are conserved targets of microRNAs [J]. Genome Res,2009,19(1) :92-105.
  • 8TIE J , FAN D. Big roles of microRNAs in tumorigenesis and tumor development [J]. Histol Histopathol, 2011 ,26 (10) : 1353-1361.
  • 9PINEAU P, VOLINIA S, MCJUNKIN K, et al. miR221 overexpression contributes to liver tumorigenesis [J]. Proc Natl Acad Sci USA,201O,107(1) :264-269.
  • 10LAN F F,WANG H,CHEN Y C,et al. Hsa-Iet-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and up-regulation of p16 [J]. Int J Cancer ,2010,128 (2) :319-331.

引证文献5

二级引证文献15

医学分子生物学杂志
2008年 第5期

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