摘要
考察了在不同pH的溶出介质中,不同厂家格列美脲片的体外溶出情况。采用中国药典2005年版溶出度第二法装置、转速50r/min、溶出介质900ml。结果显示,在水、pH 1.2盐酸、pH 6.8磷酸盐缓冲液和pH 7.8磷酸盐缓冲液中,各厂家格列美脲片的溶出度有显著性差异。
According to the second dissolution method in ChP, the dissolution of different brands of glimepiride tablets in different pH dissolution mediums was discussed. The rotate speed was 50r/min with dissolution medium volume of 900ml. The results showed that the dissolutions of four brands of glimepiride tablets in four different pH mediums （water, pH 1.2 hydrochloric acid, pH 6.8 phosphate buffer and pH 7.8 phosphate buffer） had significant difference.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2008年第10期758-761,共4页
Chinese Journal of Pharmaceuticals
关键词
格列美脲片
溶出度
溶出介质
glimepiride tablet
dissolution
dissolution medium
