摘要
目的探讨血清中心肌肌钙蛋白Ⅰ、肌红蛋白及磷酸肌酸激酶同工酶MB对判定体外循环心内直视手术中心肌损伤的价值。方法采用电化学发光分析法分别于8个时点测定30例体外循环心内直视手术患者血清心肌肌钙蛋白I(cTnI)、肌红蛋白(Myo)及磷酸肌酸激酶同工酶MB(CK-MB)水平。结果血清cTnI、Myo及CK-MB水平均在阻断主动脉即刻(T2)开始升高,与手术前T1时点相比差异均有显著性(P<0.01),其中以Myo升高最为显著,之后各指标逐渐升高,cTnI、Myo在开放主动脉后30min(T4)达峰值,CK-MB在CPB停机后2h(T5)达峰值,之后水平逐渐下降,但至CPB停机后24h(T8)仍显著高于T1时点(P<0.01)。结论cTnI在判定体外循环心内直视手术中心肌损伤的价值要优于CK-MB及Myo。
[Objective] To evaluate the clinical value of eardial troponin I （cTnI）, myoglobin（Myo） and creatine kinase MB （CK-MB） in the diagnosis of myocardial injury during open heart surgery under cardiopulrnonary bypass （CPB）. [Methods] With eleetroehemiluminescence （ECL） method, the serum levels of cTnI, Myo and CK-MB at 8 time points in 30 open heart surgery patients were measured respectively. [Results] The serum levels of cTnI , Myo and CK-MB began to increase from the onset of CPB（T2） and were significantly higher than preoperative value（T1） （P 〈 0.01）, then increased gradually, cTnI and Myo reached the peak concentrations after CPB 30 minutes （T4） and CK-MB reached the peak after CPB 2 huors T5）, the levels then decreased gradually, but after CPB 24 hours （T8） their levels were still higher than preoperative value （T1） （P〈0.01）. [Conclusion] The application of cTnI in the diagnosis of myocardial injury during open heart surgery under eardiopulmonary bypass is more valuable than CK-MB and Myo.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第19期2829-2831,2834,共4页
China Journal of Modern Medicine
