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FoxO1及其在肌纤维类型转化中的作用 被引量：1

FoxO1 and Its Effects on the Transformation of Muscle Fiber Type
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摘要 FoxO1是Fox家族中FoxO亚家族的成员之一,其氨基酸序列在不同物种间高度保守,但磷酸化位点存在差异.此外,FoxO1在不同物种间染色体定位不同.FoxO1转录活性的调节包括基因表达水平、翻译后修饰、蛋白质的稳定性及蛋白质之间的相互作用等多个层次.FoxO1在肌纤维类型转化过程中发挥重要作用,肌纤维类型与肉品质密切相关,直接影响肌肉色泽、嫩度和肌内脂肪含量.因此,研究FoxO1调控肌纤维类型转化的机理,将为改善肉品质奠定理论基础.本文系统介绍了Fox的命名与分类,FoxO1的结构特点及转录活性的调节,并着重综述了FoxO1调控肌纤维类型转化的最新研究进展. FoxO1 is an important member of the FoxO subfamily in the Fox family. Amino acid sequences of FoxO1 are highly conservative in different species, but their phosphorylation sites are different. Chromosomal locations of FoxO1 are different in various species. The regulation of FoxO1 transcriptional activity involves gene expression level, post-translational modification, protein stability, interaction of proteins et al. FoxO1 plays a key role in the process of the transformation of muscle fiber type. The muscle fiber type may directly affect meat color, meat tenderness and intramuscular fat content. Therefore, it is essential to study the mechanism of FoxO1 on regulating the transformation of muscle fiber type. In this paper, the denomination and the classification of Fox, and the construction features along with the regulation of transcription activity of FoxO1 were systematically illustrated. In addition, we focused on the latest advances of transformation of muscle fiber type regulated by FoxO1.
作者 史新娥 张辉 袁媛 杨公社
机构地区 西北农林科技大学动物科技学院动物脂肪沉积与肌肉发育实验室
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2008年第10期890-894,共5页 Chinese Journal of Biochemistry and Molecular Biology
基金 国家重点基础研究发展规划(973计划 No.2004CB117506)~~
关键词 FOXO1 肌纤维类型 转化 FoxO1 muscle fiber type transformation
分类号 S811.3 [农业科学—畜牧学]
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参考文献36

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二级参考文献34

  • 1Kaestner K H, Knochel W, Martinez D E. Unified nomenclature for the winged helix/forkhead transcription factors [ J ]. Genes Dev, 2000, 14(2) : 142-146.
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  • 4Puig O, Marr M T, Ruhf M L, et al. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway [ J]. Genes Dev, 2003, 17(16) :2006-2020.
  • 5Hribal M L, Nakae J, Kitamura T, et al. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors [J]. J Cell Biol, 2003, 162(4):535-541.
  • 6Bois P R, Brochard V F, Salin-Cantegrel A V, et al. FoxO1a-cyclic GMP-dependent kinase 1 interactions orchestrate myoblast fusion [ J]. Mol Cell Biol, 2005, 25(17):7645-7656.
  • 7Kamei Y, Miura S, Suzuki M, et al. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, downregulated type 1 (slow twitch / red muscle) fiber genes, and impaired glycemic control [J]. J Biol Chem, 2004, 279(39):41114-41123.
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共引文献19

同被引文献21

  • 1Lefaucheur L, Milan D, Ecolan P, et al. Myosin heavy chain composition of different skeletal muscles in Large White and Meishan pigs [ J ]. J Anita Sci, 2004,82 ( 7 ) : 1931-1941.
  • 2Kaestner K H, Knochel W, Martinez D E. Unified nomenclature for the winged helix/forkhead transcription factors [ J ]. Genes Dev, 2000, 14(2) :142-146.
  • 3Arden K C, Biggs W H. Regulation of the FoxO family of transcription factors by phosphatidyl inositol-3 kinase-activated signaling [ J ]. Arch Biochem Biophy,2002,403 (2) :292-298.
  • 4Puig O, Marr M T, Ruhf M L, et al. Control of cell number by drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway [ J ]. Genes Dev, 2003, 17 ( 16 ) : 2006 -2020.
  • 5Schmidt M, de Mattos S F, van der Horst A, et al. Cell cycle inhibition by FoxO forkhead transcription factors involves down regulation of cyclin D [ J ]. Mol Cell Biol, 2002, 22 ( 22 ) : 7842-7852.
  • 6Kamei Y, Miura S,Suzuki M. Skeletal Muscle FOXO1 (FKHR) transgenic mice have less skeletal, muscle mass, down-regulated type I (slow twitch/red muscle )fiber genes, and impaired glycemic control[J].J Biol Chem ,2004,279 ( 39 ) :41114-41123.
  • 7Pang Wei-Jun, Yu Tai-Yong, Bai Liang, et al. Tissue expression of porcine FoxO1 and its negative regulation during primary preadipocyte differentiation [ J ]. Mol Biol Rep ,2009,36 (1) :165- 176.
  • 8Brunet A, Sweeney L B, Sturgill J F, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J]. Science,2004,303(5 666) : 2011-2015.
  • 9Hribal M L, Nakae J, Kitamura T, et al. Regulation of insulin-like growth factor - dependent myoblast differentiation by Foxo forkhead transcription factors [ J ]. J Cell Biol, 2003,162 ( 4 ) : 535-541.
  • 10Bois P R, Brochard V F, Salin-Cantegrel A V, et al. FoxOlacyclic GMP-dependent kinase I interactions orchestrate myohlast fusion [J]. Mol Cell Biol, 2005,25 ( 17 ) :7645-7656.

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二级引证文献8

中国生物化学与分子生物学报
2008年 第10期

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