摘要
目的:观察非酒精性脂肪性肝病(NAFLD)患者血清脂联素水平的变化,探讨二者的相关性。方法:2006年2月至2008年3月间住院的NAFLD患者110例,其中单纯性脂肪肝组58例和非酒精性脂肪性肝炎(NASH)组52例;以同期本院查体中心查体健康54例个体作正常对照。分别测量身高、体质量、计算体质量指数(BMI),测空腹血清脂联素、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。数据结果应用SPSS10.0统计软件分析,组间比较采用单因素方差分析,多变量相关性分析用逐步回归分析,探讨血清脂联素与NAFLD的相关性。结果:单纯性脂肪肝患者和NASH患者血清脂联素、HDL-C水平均明显低于正常对照(均P<0.01),TG、TC、LDL-C均高于正常对照(均P<0.01)。NASH组脂联素、HDL-C水平低于单纯性脂肪肝组(均P<0.05),ALT水平明显高于单纯性脂肪肝组(P<0.01)。NASH患者血清脂联素水平与TC、TG呈负相关(r=-0.436,P<0.05;r=-0.567,P<0.01),与HDL-C呈正相关(r=0.524,P<0.01)。结论:血清脂联素水平与NAFLD患者病情严重程度相关,检测其水平有利于判断NAFLD患者病情。
Objective：To observe the changes of serum adiponectin level in patients with non-alcoholic fatty liver disease （NAFLD） ,and to study the correlation between the serum level of adiponectin and NAFLD. Methods： A total of 110 patients with NAFLD who were hospitalized from Feb. 2006 to Mar. 2008 were included in this study. The patients were divided into non-alcoholic steatohepatitis （NASH） group （n = 52, group 1 ） and simple fatty liver group （n = 58, group 2）. Fifty-four healthy volunteers were taken as normal control （group 3）. The height, weight, and body mass index （BMI） were measured in all groups. The fasting blood samples were obtained to examine serum adiponectin, TC, TG, HDL-C and LDL-C. Stepwise regression method was used to analyze relationship between the serum level of adiponectin and NAFLD. Results： The serum adiponectin and HDL-C levels in group 1 and group 2 were significantly lower than those in group 3 （P〈0.01） ; the levels of TC,TG,and LDL-C were significantly higher than those of group 3 （P〈0. 01）. The serum adiponectin in group 2 was significantly lower than that in group 1 （P〈0.05）. Lower serum adiponectin and HDL-C levels （P〈0.05） and higher AST level （P〈0.01） were found in group 2 than those in simple fatty liver patients. In non-alcoholic steatohepatitis patients,serum adiponeetin level was negatively correlated with the levels of TC, TG （r=- 0. 436, P〈0. 05;r= -0. 567, P〈0. 01, respectively） and positively correlated with the level of HDL-C （r=0. 524,P〈0.01）. Conclusion： The serum adiponeetin level is correlated with the severity of NAFLD patients,and examination of serum adiponectin may be helpful in understanding the status of NAFLD patients.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2008年第10期1201-1203,共3页
Academic Journal of Second Military Medical University
关键词
脂联素
血脂
单纯性脂肪肝
非酒精性脂肪性肝炎
adiponectin
plasma lipids
simple fatty liver disease
non-alcoholic steatohepatitis
