摘要
用正相高效液相色谱法配合衍生化法准确地测定了抗炎镇痛药布诺酚的光学纯度。方法的平均标准偏差为０．０６４％，准确度为９９．７１％～１００．２９％。
Ibuprofen is an excellent anti inflammatory and analgesic drug. It possesses a chiral carbon atom in its molecule. For the two enantiomers, only the S(+)isomer is highly active, whereas the R(-) isomer has very low activity. S isomer can be isolated by resolution from its racemoid and the R isomer can be racemized under basic condition. Consequently it is highly important to determine its enantiomeric purity. In this paper, an efficient HPLC method for determination of enantiomeric purity for ibuprofen(1) through the formation of a couple of diastereomers, N (S) (α methylbenzyl) αmethyl 4 (αmethylpropyl)benzeneacetic amide , and (S) (α methylbenzyl) αmethyl 4 (2 methyl propyl)benzeneacetic amide , was developed using Micropak Si 5 column, petroleum ether and ethyl ether (1∶1 volume) as eluate and UV detector (λ=300nm). The method is convenient, rapid and accurate. The accuracy was between 99.71% 100.25%, and the average deviation was 0.064%.
出处
《色谱》
CAS
CSCD
北大核心
1997年第5期435-437,共3页
Chinese Journal of Chromatography
关键词
高效液相色谱法
布诺酚
光学纯度
high performance liquid chromatography, ibuprofen, enantiomeric purity
