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糖尿病大鼠胃粘膜细胞色素C表达的变化 被引量:1

CHANGES OF CYTOCHROME C EXPRESSION IN GASTRIC TISSUE OF DIABETIC RATS AND ITS SIGNIFICANCE
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摘要 目的:探讨糖尿病胃粘膜变化的相关机制。方法:SD大鼠随机分为两组:对照组和糖尿病模型组,造模成功10周后免疫组织化学检测胃粘膜细胞色素C(cytC)的表达情况。结果:①模型组大鼠于造模后出现糖尿病症状;平均体重明显低于对照组(P<0.05);平均血糖浓度显著高于对照组(P<0.05)。②糖尿病大鼠胃粘膜细胞cytC蛋白阳性表达显著高于对照组(P<0.05)。结论:糖尿病大鼠胃粘膜细胞高表达cytC蛋白,引起粘膜细胞死亡,特别是凋亡增加,导致胃粘膜功能异常,这可能是糖尿病胃病的重要发病机制之一。 Objective:To investigate the mechanism of diabetes on gastric mucosa. Methods: SD rats were randomly divided into control group and diabetic group. Ten weeks later, expression of cytochrome C in gastric mueosa was detected by immunohistochemistry. Results: Typical symptoms of diabetes appeared in rats of diabetic group; the average weight was significantly lower (P〈0.05) and the average fasting concentration of blood glucose was significantly higher (P〈0.05) than that of control group. The expression of cytochrome C in mucosal cells was significantly higher(P〈0.05). Conclusion: Diabetes causes high expression of cytochrome C in mueosal cells, so as to induce cell death, especially apoptosis of gastric tissue, which partly contributes to the gastric disturbance in diabetic rats.
出处 《泸州医学院学报》 2008年第5期490-492,共3页 Journal of Luzhou Medical College
关键词 糖尿病 胃粘膜 细胞色素C 凋亡 Diabetes Gastric mucosa Cytochrome C Apoptosis
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参考文献8

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