摘要
目的探讨非糜烂型胃食管反流病(non-erosive reflux disease,NERD)合并单纯抑郁症状的治疗效果。方法使用综合医院焦虑、抑郁量表(the Hospital anxiety and depressive scale HADS)对NERD患者进行心理测评,对合并单纯抑郁症状患者按轻度、中度、重度分层随机分为常规组、治疗组、对照组三组,每组90例。常规组:奥美拉唑20mg,2次/d,西沙比利10 mg,3次/d,口服;治疗组90例,给予阿米替林12.5 mg,3次/d,奥美拉唑20 mg,2次/d,西沙比利10 mg,3次/d,口服;对照组90例,安慰剂,半片,3次/d,奥美拉唑20 mg,2次/d,西沙比利10 mg,3次/d,口服。疗程为8周,并于治疗后2、4、6、8周观察反酸、烧心、反胃、胸骨后疼痛及抑郁症状的缓解情况。结果对照组和治疗组患者治疗8周后,精神、躯体症状均显著改善,与常规组有显著差异(P(0.01),相互间也有显著差异(P(0.01)。结论抗抑郁药治疗能显著改善合并有单纯抑郁症状的NERD患者的精神和躯体两方面症状。
Objective To investigate the treatment of esophageal and gastric non-erosive reflux disease （NERD） complicated with simple depressive symptom. Methods Hospital Anxiety and Depressive Scale （HADS） was adopted to the psychological analysis of NERD. NERD patients that had simple depressive symptom were randomly divided into three groups by degree. Routine group （ n = 90） was given omeprazole （20 mg, twice per day） and cisaprice （ 10 rag, thrice per day）. Trial group （ n =90） was given amitriptyline （ 12.5 rag, thrice per day） , omeprazole （20 rag, twice per day） and cisaprice （ 10 mg, thrice per day）. Control group （n =90） was given placebo （half a tablet, thrice per day） instead of amitriptyline, omeprazole （20 mg twice per day） and cisaprice （ 10 mg, thrice per day）. Major clinical outcomes were evaluated after 2, 4, 6 and 8 weeks of treatment. Results The major clinical symptoms including depression improved obviously in the comparison and the trial group showed a significant difference from the routine group and the control group （ P 〈 0.01 ） after 8 weeks＇ treatment. Conclusion Antidepressant is effective on NERD patients in the treatment of simple depressive symptom for improving both somatic and psychological symptoms.
出处
《临床军医杂志》
CAS
2008年第5期729-731,共3页
Clinical Journal of Medical Officers
