摘要
目的：研究骨肉瘤ｐ５３蛋白过度表达与肿瘤内微血管密度（ＭＶＤ）的关系，以及它们对骨肉瘤预后的影响。方法：应用免疫组化和形态计量的方法检测８０例骨肉瘤ｐ５３蛋白表达以及ＭＶＤ计数。结果：ｐ５３蛋白过度表达与ＭＶＤ密切相关，而且两者均为影响骨肉瘤预后的重要因素，依相对危险度大小依次为ｐ５３＞ＭＶＤ。结论：结果证实ｐ５３基因对ＭＶＤ有调节作用，ｐ５３蛋白过度表达是肿瘤重要的血管生成表型之一。ｐ５３蛋白和ＭＶＤ是判估骨肉瘤预后有价值的生物学指标。
Objective: To study the relationship between overexpression of p53 protein and intratumoral microvessel density (MVD) and their prognostic significance in osteosarcoma. Methods: The expression of p53 protein and MVD count in 80 cases of osteosarcoma were determined with immunohistochemistry and morphometry. Results: The overexpression of p53 protein was significantly associated with MVD count and the two parameters were important in evaluation of the prognosis of osteosarcoma. p53 positivity was the most important index to predict the overall survival rate in patients with osteosarcoma. Conclusion: It is indicated that p53 protein involves in angiogenesis and its overexpression is an important angiogenic phenotype in neoplasm. Meanwhile, p53 protein and MVD may be useful prognostic indicators for patients with osteosarcoma.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1997年第6期496-499,共4页
Journal of Third Military Medical University
基金
全军"九五"青年基金
