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结核分支杆菌蛋白抗原表位研究进展 被引量：1

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摘要 寻找结核分支杆菌中有应用价值的蛋白抗原正逐渐成为热点,而抗原表位作为蛋白抗原引起机体免疫应答的关键部位,其研究进展对在分子水平上研究结核菌各种蛋白抗原的免疫学应用将有着很大的帮助。
作者 刘贤杰 朱中元 曾会才
机构地区 华南热带农业大学研究生学院 海南医学院附属新华医院检验科 中国热带农业科学院热带生物技术研究所
出处 《国际检验医学杂志》 CAS 2008年第10期894-895,898,共3页 International Journal of Laboratory Medicine
基金 海南省卫生厅科研立项课题(琼卫2006-61)
关键词 分支杆菌 结核 抗原 表位 变态反应和免疫学
分类号 R392 [医药卫生—免疫学]
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参考文献15

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同被引文献26

  • 1骆利敏,李明,夏虎,黄建生,王萍,董文其.乙型肝炎病毒多表位抗原基因的设计、合成及表达[J].中华微生物学和免疫学杂志,2004,24(6):426-432. 被引量：10
  • 2杨登科,靳风烁,张勇.Ag85B/IL-2融合蛋白在体外对PBMC增殖及Th1型细胞因子分泌的影响[J].医学临床研究,2006,23(2):181-183. 被引量：5
  • 3李海侠,毛旭虎.蛋白质抗原表位研究进展[J].微生物学免疫学进展,2007,35(1):54-58. 被引量：49
  • 4Svenson S,Kallenius G,Pawlowski A,et al.Towards new tuber-culosis vaccines[J].Hum Vaccin,2010,6(4):309-317.
  • 5Singhal N,Bisht D,Joshi B.Immunoprophylaxis of tuberculosis:an update of emerging trends[J].Arch Immunol Ther Exp(Warsz),2010,58(2):97-106.
  • 6Harth G,Lee B Y,Wang J,et al.Novel insights into the genetics,biochemistry,and immunocytochemistry of the30-kilodalton major extracellular protein of Mycobacterium tuberculosis[J].Infect Im-mun,1996,64(8):3038-3047.
  • 7Lim J H,Park J K,Jo E K,et al.Purification and immunoreactivi-ty of three components from the30/32-kilodalton antigen85com-plex in Mycobacterium tuberculosis[J].Infect Immun,1999,67(11):6187-6190.
  • 8Mustafa A S,Shaban F A,Abal A T,et al.Identification and HLA restriction of naturally derived Th1-cell epitopes from the secreted Mycobacterium tuberculosis antigen85B recognized by antigen-spe-cific human CD4(+)T-cell lines[J].Infect Immun,2000,68(7):3933-3940.
  • 9Colditz G A,Brewer T F,Berkey C S,et al.Efficacy of BCG vac-cine in the prevention of tuberculosis.Meta-analysis of the pub-lished literature[J].JAMA,1994,271(9):698-702.
  • 10Ben-Yedidia T,Arnon R.Towards an epitope-based human vac-cine for influenza[J].Hum Vaccin,2005,1(3):95-101.

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国际检验医学杂志
2008年 第10期

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