摘要
目的观察冠心病患者血清多项血脂的变化及相互关系,以探索血脂水平在冠心病诊断中的应用价值。方法观察194例确诊的冠心病患者及123例健康查体者血脂水平,利用全自动生化分析仪测定血清甘油三脂(TG)、总胆固醇(CH)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、脂蛋白a(Lpa)、载脂蛋白A1(ApoA1)、载脂蛋白A2(ApoA2)、载脂蛋白B(ApoB)、载脂蛋白C2(ApoC2)、载脂蛋白C3(ApoC3),建立Logistic回归模型分析冠心病发生的危险因素。结果冠心病患者血清TG、Lp(a)水平高于正常人群(P<0.01),ApoA1、ApoA2水平显著低于正常人群,(P<0.01)。在女性观察对象中,疾病组ApoB、ApoC2、ApoC3水平均显著高于对照组(P<0.01),但在男性中差异无统计学意。Logistic回归分析显示ApoC2、CH、Lip(a)、年龄、TG、性别是本研究对象冠心病发生的独立危险因素。结论血脂水平的监测对于冠心病的诊断及预后具有重要的意义。
Objective Methods Objective The significance of serum lipid in coronary heart disease patients have been evaluated by observing the variation lipid level. Results The serum lipid level of TG, TH, HDL, LDL, Lpa, ApoA1, ApoA2, ApoB, ApoC2, and Ap6C3 in 194 patients and 123 matched healthy volunteers have been observed.Serum lipid level had been measured on automatic biochemistry analyzer. Logistic regression was performed to observe the risk factors of CHD. Conclusion The serum Lp（a）and TG increased in patients group（ P 〈 0.01）, whereas serum lipid level of ApoA1, ApoA2 decreased（ P 〈 0.01）. In female observe subjects, the serum concentration of ApoB, ApoC2, ApoC3 in patients group increased compared with control group, whereas the difference has no statistic difference in male group. Multivariate logistic regression analysis showed that ApoC2, CH, lip（a）, age, TG and gender were risk factors for coronary heart disease. ApoA1 was a protective factor. Conclusion Monitoring the lipid level has chnical significance to diagnose and follow up these patients.
出处
《中国实验诊断学》
2008年第10期1259-1261,共3页
Chinese Journal of Laboratory Diagnosis
关键词
冠心病
危险因素
甘油三酯
比值比
coronary heart disease
risk factor
triglyceride
odds ratio
