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运动诱导海马内IGF-1的变化与学习记忆能力的关系 被引量：8

Relationship between Changes of Exercise Induced Insulin-like Growth Factor-1 in Hippocampus and Ability of Learning Memory(review)
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摘要 近年来的研究显示,胰岛素样生长因子-1(IGF-1)与学习记忆密切相关;运动可以使海马内的IGF-1水平升高;IGF-1可能介导运动促进学习记忆的过程,其机制之一可能是IGF-1和脑源性神经营养因子(BDNF)信号通路对Ca2+/钙调蛋白依赖性蛋白激酶Ⅱ(CAMKⅡ)、丝裂原活化蛋白激酶Ⅱ(MAPKⅡ)和突触素-1起调节作用,它们共同调节突触的可塑性,进而提高学习记忆能力。 Recent study demonstrated that insulin-like growth factor 1 （IGF- 1） could have benefits to improve the learning memory. Exercise can increase IGF-1 level in hippocampus. IGF-1 may mediate exercise inducing learning memory; one of the possible mechanism is that the IGF-1 and brain derived neurotrophic factor （BDNF） has a common regulatory capacity over calcium/calmodulin-dependent protein kinase Ⅱ （CAMK Ⅱ ）, mitogen activated protein kinase Ⅱ （MAPK Ⅱ ） and synapsin-1 ,and the convergence of multiple signaling pathways mediate synaptic plasticity and improve learning memory.
作者 孟兆辉 徐波 李世昌 黄涛 于海珍
机构地区 华东师范大学体育与健康学院 井冈山大学体育学院
出处 《中国康复理论与实践》 CSCD 2008年第10期912-915,共4页 Chinese Journal of Rehabilitation Theory and Practice
关键词 运动 胰岛素样生长因子-1 学习记忆 海马 综述 exercise insulin-like growth factor-1 learning memory hippocampus review
分类号 R338.64 [医药卫生—人体生理学]
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参考文献47

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二级参考文献28

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中国康复理论与实践
2008年 第10期

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